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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations lpxAG68D

GenelpxA

Protein ChangeG68D

Nucleotide ChangeGGT->GAT

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase LpxA, single resistance variant
Resistance To: Colistin, COLISTIN
Organisms: Chryseobacterium oranimense, Chryseobacterium indologenes, Acinetobacter baumannii
Papers: 3

Paper Information3

1

Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France.

PMID 25583710 · 2015

Mutation Information

lpxA: p.G68D / c.GGT->GAT

Protein Change: G68D
Nucleotide Change: GGT->GAT
Organisms: Chryseobacterium oranimense
Confers Resistance To: Colistin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Source Database

Reslit

2

Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.

PMID 35966843 · 2022

Mutation in lpxA contributes to colistin resistance.

Mutation Information

Protein Change: G68D
Organisms: Chryseobacterium indologenes
Confers Resistance To: Colistin
Source Database: Reslit

3

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.

PMID 20855724 · 2010

lpxA

LpxA; CARD accession: CARD:3003573

Mutation Information

Protein Change: G68D
Organisms: Acinetobacter baumannii
Confers Resistance To: COLISTIN
Effect on Function: acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase LpxA; single resistance variant
Source Database: Reference Gene CatalogCard Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research