Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.
International spread of MDR TB from Tugela Ferry, South Africa.
rpoB mutation associated with rifampin resistance
Genetic determinants of drug-resistant tuberculosis among HIV-infected patients in Nigeria.
Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis.
Mutations in the rpoB gene are responsible for rifampin resistance.
Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan.
mutations in rpoB gene associated with rifampicin resistance
Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia
Rapid detection of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates in shanghai by using the amplification refractory mutation system.
Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.
Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis strains by use of an asymmetrically split peroxidase DNAzyme.
mutations in rpoB gene confer rifampin resistance
Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis.
All mutations were experimentally validated in this study.
Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa.
Rapid and accurate detection of RMP- and INH- resistant Mycobacterium tuberculosis in spinal tuberculosis specimens by CapitalBio™ DNA microarray: a prospective validation study.
Mutations in rpoB were detected in RMP-resistant M. tuberculosis isolates.
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
most common mutation
Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand.
Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing.
Mutations in rpoB confer resistance to rifampin
Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
Mutations in rpoB are associated with rifampin resistance.
Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates from India and Mexico by a molecular beacon assay.
Mutations in the rpoB gene confer rifampin resistance
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
Mutations in rpoB are responsible for rifampin resistance.
Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea.
Disputed rpoB mutations causing low-level resistance to rifampin
The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.
Mutations in rpoB were analyzed for their effect on rifampin resistance.
Disputed rpoB Mutations in Mycobacterium tuberculosis and Tuberculosis Treatment Outcomes.
Mutations in the rpoB gene were associated with rifampin resistance in Mycobacterium tuberculosis.
Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin.
Commonest mutation
Nanopore-based targeted next-generation sequencing (tNGS): A versatile technology specialized in detecting low bacterial load clinical specimens.
All mutations were identified in the rpoB gene, with 20 located in the rifampicin resistance-determining region (RRDR) and one outside the RRDR.
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
All mutations were confirmed by DNA sequencing.
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
associated with high-level rifampicin resistance
Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.
mutations in the rpoB gene are associated with rifampicin resistance
Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.
Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.
Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.
Rifampicin mono-resistant tuberculosis in France: a 2005-2010 retrospective cohort analysis.
Mutations identified in rpoB were associated with rifampicin resistance.
Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis.
Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
Distinguishing nontuberculous mycobacteria from multidrug-resistant Mycobacterium tuberculosis, China.
Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.
A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
Consistent with phenotypic results
Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
Mutations in the resistance-determining region of rpoB (codons 511–533) were present in only 79%.
Absence of hybridization with the wild-type and mutant rpoB probes in the Genotype MTBDRplus assay detects 'disputed' rifampicin mutations.
Mutations in rpoB were identified in isolates that failed to hybridize to rpoB wild-type probes, and some of these mutations were 'disputed' as they did not consistently correlate with rifampicin resistance.
Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.
Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0.
Mutations in rpoB gene were identified in non-interpretable (NI) results and confirmed to confer rifampicin resistance through phenotypic drug susceptibility testing (pDST) and sequencing.
Interpretation of Discordant Rifampicin Susceptibility Test Results Obtained Using GeneXpert vs Phenotypic Drug Susceptibility Testing.
mutations in the rifampin resistance-determining region of the rpoB gene
Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.
rpoB
Escherichia coli rpoB mutants conferring resistance to rifampicin; CARD accession: CARD:3003288
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