Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.
Thirteen isolates showed the same nucleotide transition (ACT→ATT) resulting in a threonine→isoleucine change. In one isolate (1542), two nucleotide changes (ACT→GTT) resulted in a replacement of threonine by valine.
Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.
associated with fluoroquinolone resistance
Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis.
Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.
Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.
mutations in the quinolone resistance-determining regions of gyrA and parC
Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan.
associated with fluoroquinolone resistance
Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.
Mutations in codons 83 and 87 of gyrA are associated with fluoroquinolone resistance.
Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones.
Mutations in gyrA contribute to high-level fluoroquinolone resistance.
Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance.
Dynamics of Mutations during Development of Resistance by Pseudomonas aeruginosa against Five Antibiotics.
High-throughput automated microfluidic sample preparation for accurate microbial genomics.
Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis.
Mutations in gyrB play an important role in ciprofloxacin-resistant Pseudomonas aeruginosa.
A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical Pseudomonas aeruginosa.
Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.
associated with high-risk clones
Characterization of Antimicrobial Resistance Mechanisms in Clinical Isolates of Pseudomonas aeruginosa from a Cystic Fibrosis Patient
Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.
Mutations in gyrA are responsible for ciprofloxacin resistance in E. coli, A. baumannii, and P. aeruginosa.
The rise and the fall of a Pseudomonas aeruginosa endemic lineage in a hospital.
mutation in gyrA
Molecular Characteristics, Antimicrobial Resistance, and Biofilm Formation of Pseudomonas aeruginosa Isolated from Patients with Aural Infections in Shanghai, China.
Genomic surveillance of Pseudomonas aeruginosa in the Philippines, 2013-2014.
The role of Gene Mutations (gyrA, parC) in Resistance to Ciprofloxacin in Clinical Isolates of Pseudomonas Aeruginosa.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
Mutations in gyrA contribute to fluoroquinolone resistance.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
Effects of different mechanisms on antimicrobial resistance in Pseudomonas aeruginosa: a strategic system for evaluating antibiotics against gram-negative bacteria.
Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
Genetic and Phenotypic Variations of a Resistant Pseudomonas aeruginosa Epidemic Clone.
Prevalence, resistance mechanisms, and susceptibility of multidrug-resistant bloodstream isolates of Pseudomonas aeruginosa.
Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.
Mutations in gyrA are associated with ciprofloxacin resistance.
Efflux Pump-Driven Antibiotic and Biocide Cross-Resistance in Pseudomonas aeruginosa Isolated from Different Ecological Niches: A Case Study in the Development of Multidrug Resistance in Environmental Hotspots.
mutations in gyrA contribute to fluoroquinolone resistance
Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model.
Highly resistant strain
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies.
Mutations in gyrA are associated with ciprofloxacin resistance.
Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla (VIM-2) and bla (KPC-2) Genes That Spread on Different Genetic Environment in Colombia.
Analysis of intrahospital and global dissemination and resistome dynamics of NDM-1-producing ST773 Pseudomonas aeruginosa high-risk clone.
mutation leads to decreased susceptibility to fluoroquinolones
Differences in antimicrobial resistance between exoU and exoS isolates of Pseudomonas aeruginosa.
Mutations in gyrA were associated with fluoroquinolone resistance.
Mutations in GyrA correlate with fluoroquinolone resistance
Pseudomonas aeruginosa chronic infections in patients with bronchiectasis: a silent reservoir of carbapenemase-producing epidemic high-risk clones.
associated with resistance to fluoroquinolones
Identification of a Potential High-Risk Clone and Novel Sequence Type of Carbapenem-Resistant Pseudomonas aeruginosa in Metro Manila, Philippines.
found in multiple isolates
Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation.
Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7.
Mutation in gyrA contributes to fluoroquinolone resistance.
Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa.
Variable In Vitro Efficacy of Delafloxacin on Multidrug-Resistant Pseudomonas aeruginosa and the Detection of Delafloxacin Resistance Determinants.
mutation in quinolone-resistance-determining region
Antibiotics Resistance Profile of Clinical Isolates of Pseudomonas aeruginosa Obtained from Farwaniya Hospital in Kuwait Using Phenotypic and Molecular Methods.
Exploring the potential role of GyrA inhibiting quinoline analog: an in silico study.
All mutations are in the quinolone resistance-determining region (QRDR) of gyrA.
Molecular and genomic insights into multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa causing burn wound infections in Bangladesh.
Detection of the ST111 Global High-Risk Pseudomonas aeruginosa Clone in a Subway Underpass.
associated with quinolone resistance
First nationwide survey on Pseudomonas aeruginosa in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.
Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.
The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility.
Isolation of NDM-1-producing multidrug-resistant Pseudomonas putida from a paediatric case of acute gastroenteritis, India.
Prevalence and fluoroquinolone resistance of pseudomonas aeruginosa in a hospital of South China.
Mutation in gyrA (Thr83Ile) is linked to fluoroquinolone resistance
Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans.
The gyrA83 mutation was detected in two patients (patients #2 and #4) during fluoroquinolone therapy.
Clinical and Molecular Epidemiology of Multidrug-Resistant P. aeruginosa Carrying aac(6')-Ib-cr, qnrS1 and blaSPM Genes in Brazil.
Long-term Persistence of an Extensively Drug-Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.
Type II Topoisomerase Mutations in Ciprofloxacin-Resistant Strains of Pseudomonas aeruginosa.
Most common mutation
Antibiotic resistance determinants in a Pseudomonas putida strain isolated from a hospital.
Mutation in gyrA leads to fluoroquinolone resistance.
Genetic Context of the blaCARB-2-Containing Integron and Mutational Resistome in Multidrug-Resistant Pseudomonas aeruginosa Strains
T83I substitution in GyrA is associated with fluoroquinolone resistance.
Association between possession of ExoU and antibiotic resistance in Pseudomonas aeruginosa.
Multidrug resistant Pseudomonas aeruginosa in Estonian hospitals.
Characterization of antimicrobial resistance mechanisms in carbapenem-resistant Pseudomonas aeruginosa carrying IMP variants recovered from a Mexican Hospital.
Characterization of gyrA and parC mutations in ciprofloxacin-resistant Pseudomonas aeruginosa isolates from Tehran hospitals in Iran.
Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa.
Epidemiology and molecular characterization of the antimicrobial resistance of Pseudomonas aeruginosa in Chinese mink infected by hemorrhagic pneumonia.
Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds.
The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic.
A bittersweet fate: detection of serotype switching in Pseudomonas aeruginosa.
Resistant gyrA alleles were found in 95% of O12 ST111 isolates and 86% of all O12 isolates.
Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceae isolates from Brazil.
Multiple mutations in gyrA and parC genes are associated with high-level fluoroquinolone resistance.
Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa.
Multidrug Resistant Pseudomonas aeruginosa Causing Prosthetic Valve Endocarditis: A Genetic-Based Chronicle of Evolving Antibiotic Resistance.
Present in all isolates
Genomic characterization of a local epidemic Pseudomonas aeruginosa reveals specific features of the widespread clone ST395.
Quinolone-resistant clinical strains of Pseudomonas aeruginosa isolated from University Hospital in Tunisia.
Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in Vietnam.
Evolution of Antibiotic Resistance in Biofilm and Planktonic Pseudomonas aeruginosa Populations Exposed to Subinhibitory Levels of Ciprofloxacin.
mutations in gyrA were exclusive to CIP-evolved planktonic populations
Ciprofloxacin binding to GyrA causes global changes in the proteome of Pseudomonas aeruginosa.
The T83→I mutation in GyrA confers ciprofloxacin resistance.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
Mutations in gyrA and parC are associated with fluoroquinolone resistance in various bacterial species.
Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C.
Antimicrobial resistance and novel mutations detected in the gyrA and parC genes of Pseudomonas aeruginosa strains isolated from companion dogs.
Mutations in gyrA were significantly more common in strains from the infected group than in those from the healthy group
High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.
Development of in vitro resistance to fluoroquinolones in Pseudomonas aeruginosa.
mutations in gyrA contribute to fluoroquinolone resistance in P. aeruginosa
Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness.
Molecular Evolution of the Pseudomonas aeruginosa DNA Gyrase gyrA Gene.
Mutations in gyrA are associated with quinolone resistance
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
Unveiling the microevolution of antimicrobial resistance in selected Pseudomonas aeruginosa isolates from Egyptian healthcare settings: A genomic approach.
Global genomic diversity of Pseudomonas aeruginosa in bronchiectasis.
Mutations in gyrA lead to fluoroquinolone resistance
Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis.
Monitoring of Pseudomonas aeruginosa mutational resistome dynamics using an enrichment panel for direct sequencing of clinical samples.
Detected in ST175 isolate.
The contribution of antibiotic resistance mechanisms in clinical Burkholderia cepacia complex isolates: an emphasis on efflux pump activity.
gyrA
Burkholderia dolosa gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3004860
High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species.
gyrA
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
gyrA
Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data.
gyrA
DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa.
gyrA
Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003684
Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile.
Clostridioides difficile gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003995
gyrA and parC mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa from Nini Hospital in north Lebanon.
Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003684
Role of Efflux in Antibiotic Resistance of Achromobacter xylosoxidans and Achromobacter insuavis Isolates From Patients With Cystic Fibrosis.
Mutations in QRDR of gyrA associated with ciprofloxacin resistance.
Molecular and Clinical Epidemiology of Salmonella Paratyphi A Isolated from Patients with Bacteremia in Nepal.
All isolates had a same single mutation C248T in gyrA encoding Ser83Phe; however, no mutation was found in gyrB, parC, and parE.
Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.
Resistance development in Escherichia coli to delafloxacin at pHs 6.0 and 7.3 compared to ciprofloxacin.
Mutations in gyrA were seen in all derivatives challenged with CIP, regardless of pH.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
Selection for Antimicrobial Resistance in Foodborne Pathogens through Exposure to UV Light and Nonthermal Atmospheric Plasma Decontamination Techniques.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients.
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