Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Mutations in InhA reduce NADH binding affinity, leading to isoniazid resistance.
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Tuberculosis drug resistance mutation database.
The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
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