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Browse Mutations spoTS305P

GenespoT

guanosine-3',5'-bispyrophosphate (ppGpp) 3'-pyrophosphohydrolase

Protein ChangeS305P

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Nitrofurantoin
Organisms: Escherichia coli, Salmonella enterica
Papers: 1

Paper Information1

1

Molecular mechanisms of collateral sensitivity to the antibiotic nitrofurantoin.

PMID 31986134 · 2020

Mutation in the coding region of spoT leads to increased nitroreductase expression, causing heightened susceptibility to nitrofurantoin.

Mutation Information

Protein Change: S305P
Organisms: Escherichia coli, Salmonella enterica
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
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PubMed
NCBI Pathogens
UniProt
CARD
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PointFinder DB
AMR Rules

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Nitrofurantoin

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research