ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeR322M

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased use of D-serine, broadened specificity for utilization of other D-amino acids
Resistance To: Vancomycin
Organisms: Enterococcus casseliflavus, Escherichia coli
Papers: 1

Paper Information1

Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.

PMID 9545431 · 1998

Mutations in VanC2 alter the specificity of the ligase, affecting vancomycin resistance.

Mutation Information

VanC2: p.R322M

Protein Change: R322M
Organisms: Enterococcus casseliflavus, Escherichia coli
Confers Resistance To

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Mutation Information