ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeF250Y

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The F250Y mutation decreases the use of D-serine and broadens the specificity for other D-amino acids.
Resistance To: Vancomycin
Organisms: Escherichia coli, Enterococcus casseliflavus
Papers: 1

Paper Information1

Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases.

PMID 9545431 · 1998

Mutants exhibit altered substrate specificity and reduced vancomycin resistance

Mutation Information

vanC2: p.F250Y

Protein Change: F250Y
Organisms: Escherichia coli, Enterococcus casseliflavus
Confers Resistance To

Browse AMR Mutations

Mutation Information