Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.
The Ser130Gly substitution prevents irreversible cross-linking of the inhibitor to Ser130, leading to resistance.
Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
Mutant enzymes with replacements of Met69, Arg244, and Asn276 had been reported to confer resistance to beta-lactam-clavulanate combinations.
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