ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeG172D

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: strongly impair the dimerization of MexZ and its subsequent binding to the regulatory sequences upstream of mexXY
Resistance To: Aminoglycoside
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.

Mutations in mexZ lead to overexpression of mexXY-OprM efflux pump, resulting in aminoglycoside resistance.

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