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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations mgrBA98T

GenemgrB

regulator

Nucleotide ChangeA98T

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: compromises MgrB activity
Resistance To: Trimethoprim
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant E. coli.

PMID 38032208 · 2023

mgrB loss-of-function mutations lead to PhoQP hyperactivation and trimethoprim resistance.

Mutation Information

Nucleotide Change: A98T
Organisms: Escherichia coli
Confers Resistance To: Trimethoprim

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

compromises MgrB activity

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research