ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeN967I

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: confers high-dose methicillin tolerance and promotes heterogeneous-to-homogeneous conversion of β-lactam resistance, DNA-directed RNA polymerase subunit beta RpoB
Resistance To: Methicillin, BETA-LACTAM
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus.

PMID 23877693 · 2013

The rpoB (N967I) mutation was shown to confer high-dose methicillin tolerance and promote heterogeneous-to-homogeneous conversion of β-lactam resistance.

rpoB

Mutation Information

rpoB: p.N967I

Protein Change: N967I
Organisms: Staphylococcus aureus

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Mutation Information