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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations gyrBR447L

GenegyrB

Protein ChangeR447L

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB, single resistance variant
Resistance To: Ciprofloxacin|Moxifloxacin, Fluoroquinolones, QUINOLONE
Organisms: Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii
Papers: 3

Paper Information3

1

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID 12384345 · 2002

gyrB

Clostridioides difficile gyrB conferring resistance to fluoroquinolones; CARD accession: CARD:3004562

Mutation Information

Protein Change: R447L
Organisms: Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Ciprofloxacin|MoxifloxacinQUINOLONEFluoroquinolones

Effect on Function

DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB; single resistance variant

Source Database

ReslitReference Gene CatalogCard Database

2

Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.

PMID 29682562 · 2018

Mutation Information

Protein Change: R447L
Confers Resistance To: Fluoroquinolones
Source Database: Reslit

3

Acquired immune deficiency syndrome and the developing nervous system.

PMID 1981886 · 1990

gyrB

Mutation Information

Protein Change: R447L
Organisms: Clostridioides difficile
Confers Resistance To: QUINOLONE
Effect on Function: DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
Source Database: Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research