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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBS488T

GenerpoB

Protein ChangeS488T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: Rifampin|Rifaximin, Rifampicin
Organisms: Clostridium difficile, Clostridium ljungdahlii
Papers: 1

Paper Information1

1

Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile.

PMID 18559647 · 2008

Mutations in rpoB are associated with rifampin and rifaximin resistance in C. difficile

Clostridioides difficile rpoB with mutation conferring resistance to rifampicin; CARD accession: CARD:3004563

Mutation Information

Protein Change: S488T
Organisms: Clostridium difficile, Clostridium ljungdahlii

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Confers Resistance To

Rifampin|RifaximinRifampicin

Effect on Function

single resistance variant

Source Database

ReslitCard Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research