ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT70P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased PgsA activity
Resistance To: Daptomycin
Organisms: Enterococcus faecium
Papers: 1

Paper Information1

Evolution of Enterococcus faecium in Response to a Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies.

PMID 35543524 · 2022

The mutation pgsA T70P was observed in DAP-resistant isolates and is associated with decreased PgsA activity, leading to reduced phosphatidylglycerol (PG) levels and contributing to DAP resistance.

Mutation Information

pgsA: p.T70P

Protein Change: T70P
Organisms: Enterococcus faecium

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Mutation Information