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Browse Mutations rdxAA68E

GenerdxA

oxygen-insensitive NADPH nitroreductase

Protein ChangeA68E

Validation StatusEstablished

Databases

Card Database

Overview

Mechanism: single resistance variant
Resistance To: Metronidazole
Organisms: Helicobacter pylori
Papers: 1

Paper Information1

1

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.

PMID 9622362 · 1998

Helicobacter pylori rdxA mutation conferring resistance to metronidazole; CARD accession: CARD:3007055

Mutation Information

Protein Change: A68E
Organisms: Helicobacter pylori
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Metronidazole

Effect on Function

single resistance variant

Source Database

Card Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research