Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis.
Mutations in the pncA gene lead to reduced binding affinity of PZA to PZase, resulting in pyrazinamide resistance.
Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.
All mutations are missense mutations in the pncA gene associated with pyrazinamide resistance.
Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis.
Mutations in pncA lead to decreased pyrazinamidase activity, contributing to pyrazinamide resistance.
A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.
Mutations in pncA are associated with pyrazinamide resistance.
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394
Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide; CARD accession: CARD:3003394
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