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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBL449M

GenerpoB

Protein ChangeL449M

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: Rifampicin
Organisms: Mycobacterium tuberculosis
Papers: 2

Paper Information2

1

Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola.

PMID 34641802 · 2021

mutations in rpoB associated with rifampicin resistance

Mutation Information

Protein Change: L449M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Source Database

Reslit

2

PMID 978-92-4-008241-0

Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin; CARD accession: CARD:3003283

Mutation Information

Protein Change: L449M
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research