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Browse Mutations walKR263C

GenewalK

histidine kinase

Protein ChangeR263C

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene Catalog

Overview

Mechanism: cell wall metabolism sensor histidine kinase WalK, single resistance variant
Resistance To: DAPTOMYCIN, Daptomycin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.

PMID 16723576 · 2006

Staphylococcus aureus walK with mutation conferring resistance to daptomycin; CARD accession: CARD:3003794

Mutation Information

Protein Change: R263C
Organisms: Staphylococcus aureus
Confers Resistance To: Daptomycin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

single resistance variant

Source Database

Card Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research