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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations gyrAA118T

GenegyrA

Protein ChangeA118T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: DNA gyrase subunit A GyrA, single resistance variant
Resistance To: Ciprofloxacin|Moxifloxacin, QUINOLONE, Fluoroquinolones
Organisms: Clostridium difficile, Clostridioides difficile
Papers: 2

Paper Information2

1

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID 12384345 · 2002

gyrA

Clostridioides difficile gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003995

Mutation Information

Protein Change: A118T
Organisms: Clostridium difficile, Clostridioides difficile
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Ciprofloxacin|MoxifloxacinQUINOLONEFluoroquinolones

Effect on Function

DNA gyrase subunit A GyrA; single resistance variant

Source Database

ReslitReference Gene CatalogCard Database

2

Acquired immune deficiency syndrome and the developing nervous system.

PMID 1981886 · 1990

gyrA

Mutation Information

Protein Change: A118T
Organisms: Clostridioides difficile
Confers Resistance To: QUINOLONE
Effect on Function: DNA gyrase subunit A GyrA
Source Database: Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research