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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBV1143D

GenerpoB

Protein ChangeV1143D

Validation StatusEstablished

Databases

Reference Gene Catalog

Overview

Mechanism: DNA-directed RNA polymerase subunit beta RpoB
Resistance To: FIDAXOMICIN
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

1

Characterization of a clinical Clostridioides difficile isolate with markedly reduced fidaxomicin susceptibility and a V1143D mutation in rpoB.

PMID 30247587 · 2019

rpoB

Mutation Information

Protein Change: V1143D
Organisms: Clostridioides difficile
Confers Resistance To: FIDAXOMICIN

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

DNA-directed RNA polymerase subunit beta RpoB

Source Database

Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research