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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBV1143F

GenerpoB

Protein ChangeV1143F

Validation StatusEstablished

Databases

Reference Gene Catalog

Overview

Mechanism: DNA-directed RNA polymerase subunit beta RpoB
Resistance To: FIDAXOMICIN
Organisms: Clostridioides difficile
Papers: 2

Paper Information2

1

Improved long-acting fertility regulating agents: what are the problems?

PMID 385987 · 1979

rpoB

Mutation Information

Protein Change: V1143F
Organisms: Clostridioides difficile
Confers Resistance To: FIDAXOMICIN

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

DNA-directed RNA polymerase subunit beta RpoB

Source Database

Reference Gene Catalog

2

Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin.

PMID 29253242 · 2018

rpoB

Mutation Information

Protein Change: V1143F
Organisms: Clostridioides difficile
Confers Resistance To: FIDAXOMICIN
Effect on Function: DNA-directed RNA polymerase subunit beta RpoB
Source Database: Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research