GenekatG
Protein ChangeR418Q
Validation StatusCandidate
Databases
Reslit
Overview
- Mechanism
- loss of catalase-peroxidase activities
- Resistance To
- isoniazid
- Organisms
- Mycobacterium tuberculosis
- Papers
- 1
Paper Information1
1
Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.
The Arg418->Gln mutation in KatG leads to loss of catalase-peroxidase activities and confers isoniazid resistance.
Mutation Information
- Protein Change
- R418Q
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- isoniazid
- Effect on Function
- loss of catalase-peroxidase activities
- Source Database
- Reslit
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