ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeY64S

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe(2+) Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide.

PMID 34095218 · 2021

All mutations are in the pncA gene, which encodes pyrazinamidase, and are associated with reduced PZA binding affinity and resistance.

Mutation Information

pncA: p.Y64S

Protein Change: Y64S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Pyrazinamide
Source Database: Reslit

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