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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations blaTEM-1S130G

Protein ChangeS130G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: prevents irreversible cross-linking of the inhibitor to Ser130
Resistance To: penicillins
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

PMID 15981999 · 2005

The Ser130Gly substitution prevents irreversible cross-linking of the inhibitor to Ser130, leading to resistance.

Mutation Information

blaTEM-1: p.S130G

Protein Change: S130G
Organisms: Escherichia coli
Confers Resistance To: penicillins

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

prevents irreversible cross-linking of the inhibitor to Ser130

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research