GeneparE
Protein ChangeI460V
Nucleotide ChangeA1380G
Validation StatusSupported
Databases
Reslit
Overview
- Resistance To
- ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin, fluoroquinolones, moxifloxacin|levofloxacin|gemifloxacin
- Organisms
- Streptococcus pneumoniae
- Papers
- 3
Paper Information3
1
Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.
Mutation in parE leads to quinolone resistance
Mutation Information
- Protein Change
- I460V
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin
- Source Database
- Reslit
2
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.
Mutation detected in quinolone-resistant strains
Mutation Information
- Protein Change
- I460V
- Nucleotide Change
- A1380G
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
3
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Protein Change
- I460V
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- moxifloxacin|levofloxacin|gemifloxacin
- Source Database
- Reslit
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