ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2a

penicillin-binding protein

Protein ChangeK336G

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Vancomycin
Organisms: Enterococcus faecalis
Papers: 1

Paper Information1

Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis.

PMID 40007607 · 2025

A lysine-to-glycine substitution at position 336 of PBP2A affects the protein's flexibility and stability near the membrane interface.

Mutation Information

pbp2a: p.K336G

Protein Change: K336G
Organisms: Enterococcus faecalis
Confers Resistance To: Vancomycin
Source Database: Reslit

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