ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemecA

penicillin-binding protein 2'

Nucleotide ChangeT1577A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased transcription rate
Organisms: Staphylococcus aureus, Staphylococcus sciuri
Papers: 1

Paper Information1

Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus.

PMID 11274099 · 2001

The wild-type mecA gene from S. sciuri is not resistant, but a promoter mutation leads to resistance.

Mutation Information

mecA: c.T1577A

Nucleotide Change: T1577A
Organisms: Staphylococcus aureus, Staphylococcus sciuri
Effect on Function: increased transcription rate

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