GenerpoB
Protein ChangeS531L
Nucleotide ChangeT531C
Validation StatusSupported
Databases
Reslit

Overview

Resistance To
rifampin, rifampicin|rifabutin, rifampicin
Organisms
Mycobacterium tuberculosis
Papers
9
Paper Information9
1

Drug-susceptible Mycobacterium tuberculosis Beijing genotype does not develop mutation-conferred resistance to rifampin at an elevated rate.

PMID 12682139 · 2003

Mutations in rpoB gene associated with rifampin resistance

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
2

Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.

PMID 15917513 · 2005

all mutations are in the rpoB gene and confer resistance to rifampin

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
3

Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection.

PMID 15338545 · 2004

Mutations in rpoB are associated with rifampin resistance in M. tuberculosis.

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
4

Rapid detection of rifampin resistance in Mycobacterium tuberculosis by Pyrosequencing technology.

PMID 16757581 · 2006

Mutations in the rpoB gene are associated with rifampin resistance

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
5

Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.

PMID 15958167 · 2005

Mutations in the rpoB gene were identified through sequencing of gene fragments.

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampicin|rifabutin
Source Database
Reslit
6

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin.

PMID 19146699 · 2009

Some mutations in the rpoB gene can reveal drug-resistant phenotype only in a specific genetic background of the host.

Mutation Information

Protein Change
S531L
Nucleotide Change
T531C
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
7

Validation of the GenoType MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam.

PMID 20525271 · 2010

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampicin
Source Database
Reslit
8

Drug resistant Mycobacterium tuberculosis of the Beijing genotype does not spread in Sweden.

PMID 20531942 · 2010

associated with multidrug resistance

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampicin
Source Database
Reslit
9

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Protein Change
S531L
Organisms
Mycobacterium tuberculosis
Confers Resistance To
rifampin
Source Database
Reslit
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