ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2a

penicillin-binding protein

Protein ChangeD440N

Nucleotide ChangeG1320A

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Penicillin|Cefotaxime
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

PMID 15980366 · 2005

Mutations G425S and D440N in PBP 2a are associated with reduced susceptibility to penicillin G and cefotaxime.

Mutation Information

pbp2a: p.D440N / c.G1320A

Protein Change: D440N
Nucleotide Change: G1320A
Organisms

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Mutation Information