ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemecA

penicillin-binding protein 2'

Protein ChangeM483I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: may be associated with a change in the function of PBP2a resulting in oxacillin susceptibility
Resistance To: Oxacillin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Correlation of penicillin Binding Protein 2a Detection with Oxacillin Resistance in Staphylococcus aureus and discovery of a novel penicillin Binding Protein 2a mutation.

PMID 16145104 · 2005

The M483I amino acid substitution in PBP2a has not been previously reported and may be associated with a change in the function of PBP2a resulting in oxacillin susceptibility.

Mutation Information

mecA: p.M483I

Protein Change: M483I
Organisms: Staphylococcus aureus

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Mutation Information