Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.
Single point mutations in gyrA are associated with reduced susceptibility to fluoroquinolones.
Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.
Mutations in gyrA alone or in combination with parC were linked to nalidixic acid resistance.
gyrA
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
gyrA
Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
Most frequent mutation
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
Single nucleotide exchange at position 83
Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease.
Mutations in gyrA were associated with quinolone resistance.
Isolation and molecular characterization of fluoroquinolone-resistant Escherichia coli from poultry litter.
Single mutation at Ser83Leu or Asp87Asn associated with low-level resistance; double mutations at Ser83Leu and Asp87Asn associated with high-level resistance.
Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.
mutations in the quinolone resistance-determining regions of gyrA and parC
Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children.
Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.
Mutation in gyrA leads to fluoroquinolone resistance.
Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.
Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California.
Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.
Molecular Diagnostic Technologies in Clinical Microbiology
A novel mechanism of transposon-mediated gene activation.
Mutation in gyrA was shown to contribute to fluoroquinolone resistance.
Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi.
All 18 isolates from Laos and the two genome sequences (Boryong and Ikeda) showed the same mutation.
Impact of recA on levofloxacin exposure-related resistance development.
Additional mutations in gyrA (e.g., S84A, S84L, S84P, E88G, and E88K) were found in all the levofloxacin-resistant isolates.
The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.
Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
Mutations in the quinolone resistance-determining region of the gyrA gene cause quinolone resistance.
Ciprofloxacin-resistant Shigella sonnei among men who have sex with men, Canada, 2010.
Emergence of quinolone resistance among extended-spectrum beta-lactamase-producing Enterobacteriaceae in the Central African Republic: genetic characterization.
The influence of reduced susceptibility to fluoroquinolones in Salmonella enterica serovar Typhi on the clinical response to ofloxacin therapy.
Mutations in gyrA were associated with reduced susceptibility to fluoroquinolones.
Prominence of an O75 clonal group (clonal complex 14) among non-ST131 fluoroquinolone-resistant Escherichia coli causing extraintestinal infections in humans and dogs in Australia.
Comparison of the prevalences and antimicrobial resistances of Escherichia coli isolates from different retail meats in the United States, 2002 to 2008.
Ciprofloxacin-resistant Escherichia coli in Central Greece: mechanisms of resistance and molecular identification.
Chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms among broad-spectrum-cephalosporin-resistant Escherichia coli isolates recovered from companion animals in the USA.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
associated with ciprofloxacin resistance
Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii.
Mutation in gyrA (S83L) was detected in all A. baumannii isolates studied.
Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
Characteristics of Quinolone Resistance in Escherichia coli Isolates from Humans, Animals, and the Environment in the Czech Republic.
Common mutation in quinolone-resistant isolates
Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro.
Mutation in gyrA gene was identified through whole-genome resequencing.
Quinolone Resistance Reversion by Targeting the SOS Response.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
Evaluation of Fluoroquinolone Resistance in Clinical Avian Pathogenic Escherichia coli Isolates from Flanders (Belgium).
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
Phylogenomic Investigation of Increasing Fluoroquinolone Resistance among Belgian Cases of Shigellosis between 2013 and 2018 Indicates Both Travel-Related Imports and Domestic Circulation.
Mutations in gyrA are associated with ciprofloxacin resistance.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
High Risk Clone: A Proposal of Criteria Adapted to the One Health Context with Application to Enterotoxigenic Escherichia coli in the Pig Population.
Phylogroup stability contrasts with high within sequence type complex dynamics of Escherichia coli bloodstream infection isolates over a 12-year period.
associated with fluoroquinolone resistance
Characterization of antibiotic resistance in Escherichia coli isolates from Black-headed gulls (Larus ridibundus) present in the city of Novi Sad, Serbia.
Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.
Mutations in gyrA are responsible for ciprofloxacin resistance in E. coli, A. baumannii, and P. aeruginosa.
The Pheno- and Genotypic Characterization of Porcine Escherichia coli Isolates.
International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.
Multidrug-Resistant Lineage of Enterotoxigenic Escherichia coli ST182 With Serotype O169:H41 in Airline Waste.
The S83L mutation in gyrA confers resistance to fluoroquinolones.
Genomic epidemiology of persistently circulating MDR Shigella sonnei strains associated with men who have sex with men (MSM) in Belgium (2013-19).
Phylogenetic Analysis Reveals Distinct Evolutionary Trajectories of the Fluoroquinolones-Resistant Escherichia coli ST1193 From Fuzhou, China.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
The Darkest Place Is under the Candlestick-Healthy Urogenital Tract as a Source of Worldwide Disseminated Extraintestinal Pathogenic Escherichia coli Lineages.
Mutation in gyrA (S83L) confers resistance to fluoroquinolones.
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Mutations in gyrA are common in quinolone-resistant Salmonella isolates.
Whole-Genome Sequencing-Based Antimicrobial Resistance Characterization and Phylogenomic Investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Positive Escherichia coli Strains Collected From Hospital Patients in Benin in 2019.
A Descriptive Analysis of Urinary ESBL-Producing-Escherichia coli in Cerdanya Hospital.
associated with ciprofloxacin resistance
Genetic diversity and multidrug resistance of phylogenic groups B2 and D in InPEC and ExPEC isolated from chickens in Central China.
Mutations in gyrA confer resistance to quinolones.
Acquired resistome and plasmid sequencing of mcr-1 carrying MDR Enterobacteriaceae from poultry and their relationship to STs associated with humans.
Prevalence and molecular characteristics of carbapenem-resistant Escherichia coli isolated from dogs in South Korea.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
Mutations in gyrA and parC contribute to quinolone resistance.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Mutations in the QRDR of gyrA contribute to fluoroquinolone resistance.
Antibiotic resistant bacteria survive treatment by doubling while shrinking.
This mutation was found in eight of the nine evolutionary experiments.
Genotypic and phenotypic analyses of two distinct sets of Pseudomonas aeruginosa urinary tract isolates.
associated with high-level resistance to fluoroquinolones
Genetic basis of multidrug resistance in Acinetobacter clinical isolates in Taiwan.
Quinolone resistance in Escherichia coli from Accra, Ghana.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
Mutations in gyrA contribute to fluoroquinolone resistance in various bacterial species.
Prevalence and genetic characteristics of antimicrobial-resistant Escherichia coli in wild birds in Japan.
Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan.
Resistance Mechanisms of Fluoroquinolone in Escherichia coli Isolated from Taihe Black-Boned Silky Fowl Exhibiting Abnormally Slow Fluoroquinolone Metabolism in Jiangxi, China.
The GyrA-S83Q mutation was reported as novel in this study.
Antimicrobial Resistance Genotypes and Mobile Genetic Elements of Poultry-Derived Escherichia coli: A Retrospective Genomic Study from the United States.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
Cost of Altered Translation Accuracy Shapes Adaptation to Antibiotics in E. coli.
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
gyrA
Antimicrobial susceptibilities and plasmid contents of Neisseria gonorrhoeae isolates from commercial sex workers in Dhaka, Bangladesh: emergence of high-level resistance to ciprofloxacin.
Mutations in gyrA were associated with ciprofloxacin resistance.
Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.
Double mutation at Ser83 and Asp87 enhances ciprofloxacin resistance
Escherichia coli gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003294
Topoisomerase IV is a target of quinolones in Escherichia coli.
Mutations in gyrA contribute to quinolone resistance in E. coli.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
Incidence of quinolone resistance over the period 1986 to 1998 in veterinary Salmonella isolates from Germany.
Mutations in gyrA were associated with quinolone resistance in Salmonella isolates.
Sparfloxacin selects gyrase mutations in first-step Mycoplasma hominis mutants, whereas ofloxacin selects topoisomerase IV mutations.
In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations.
Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents.
mutation in gyrA leads to resistance
An imported enteric fever caused by a quinolone-resistant Salmonella Typhi.
Point mutation in the gyrA gene leading to quinolone resistance.
Non-Target Gene Mutations in the Development of Fluoroquinolone Resistance in Escherichia coli.
Mutation in the quinolone resistance-determining region (QRDR) of gyrA
Epidemiology of nalidixic acid resistance and TEM-1- and TEM-52-mediated ampicillin resistance of Shigella sonnei isolates obtained in Korea between 1980 and 2000.
Single point mutation in the QRDR of gyrA
Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China.
Molecular epidemiology of extended-spectrum beta-lactamase-producing, fluoroquinolone-resistant isolates of Klebsiella pneumoniae in Taiwan.
Mutations in gyrA were associated with quinolone resistance in K. pneumoniae isolates.
Laboratory detection of Haemophilus influenzae with decreased susceptibility to nalidixic acid, ciprofloxacin, levofloxacin, and moxifloxacin due to GyrA and ParC mutations.
Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon.
Mutation in gyrA was suggested as a possible cause of reduced susceptibility to ciprofloxacin.
Epidemiologic relationship between fluoroquinolone-resistant Salmonella enterica Serovar Choleraesuis strains isolated from humans and pigs in Taiwan (1997 to 2002).
Mutations in gyrA were associated with fluoroquinolone resistance in Salmonella enterica serovar Choleraesuis.
Antimicrobial susceptibility patterns of Salmonella enterica serotype typhi in eastern Nepal.
Mutations in gyrA were associated with reduced susceptibility to ciprofloxacin.
Characteristics of non-typhoidal Salmonella isolates from human and broiler-chickens in southwestern Seoul, Korea.
Mutations in gyrA were associated with reduced susceptibility to ciprofloxacin.
High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi.
Mutations in the QRDRs of the gyrA gene were responsible for fluoroquinolone resistance in Corynebacterium macginleyi.
The trials of the returning traveler: ciprofloxacin failure in enteric fever.
Mutation in gyrA led to ciprofloxacin failure despite MIC being below resistance cutoff.
Chronological study of antibiotic resistances and their relevant genes in Korean avian pathogenic Escherichia coli isolates.
Novel approach for comparing the abilities of quinolones to restrict the emergence of resistant mutants during quinolone exposure.
Mutations in gyrA were identified as key determinants of quinolone resistance in E. coli.
Pharmacokinetic/pharmacodynamic analysis of the influence of inoculum size on the selection of resistance in Escherichia coli by a quinolone in a mouse thigh bacterial infection model.
The gyrA gene was studied for mutations that confer resistance to quinolones.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
Mechanisms of fluoroquinolone resistance in Escherichia coli isolates from food-producing animals.
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
Mutations in gyrA are responsible for fluoroquinolone resistance.
Recent independent emergence of multiple multidrug-resistant Serratia marcescens clones within the United Kingdom and Ireland.
Mutations in gyrA are associated with ciprofloxacin resistance.
Quinolone-resistant Shigella flexneri isolated in a patient who travelled to India.
Resistance Pattern and Molecular Characterization of Enterotoxigenic Escherichia coli (ETEC) Strains Isolated in Bangladesh.
Single mutation in gyrA observed in nalidixic acid resistant ETEC strains.
Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.
Common mutation in gyrA at position 83
Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli.
Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015.
mutations in gyrA and parC were found in PMQR-harboring isolates
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal.
Mutation in DNA gyrase gene associated with increased MICs against fluoroquinolones.
Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolated from diseased animals in Taiwan.
In Vitro Resistance Selection in Shigella flexneri by Azithromycin, Ceftriaxone, Ciprofloxacin, Levofloxacin, and Moxifloxacin.
A gyrA mutant (Ser83Leu) with reduced fluoroquinolone susceptibility was isolated.
Emerging Treatment Options for Mycoplasma genitalium Infections
Mutations in the gyrA gene are associated with fluoroquinolone resistance.
Pefloxacin as a surrogate marker for quinolone susceptibility in Salmonella enterica serovars Typhi & Paratyphi A in India.
Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones.
The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae.
Molecular Characterization of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Among the Pediatric Population in Qatar.
Ciprofloxacin Pharmacokinetics/Pharmacodynamics against Susceptible and Low-Level Resistant Escherichia coli Isolates in an Experimental Ascending Urinary Tract Infection Model in Mice.
Mutation in gyrA contributes to low-level resistance to ciprofloxacin.
Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan.
associated with fluoroquinolone resistance
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates Belonging to Major Endemic Clones in South America.
Detection of gyrA and parC Mutations and Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Klebsiella pneumoniae.
Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran.
Mutation in gyrA at amino acid 83 (serine to leucine)
Overexpression of Efflux Pumps, Mutations in the Pumps' Regulators, Chromosomal Mutations, and AAC(6′)-Ib-cr Are Associated With Fluoroquinolone Resistance in Diverse Sequence Types of Neonatal Septicaemic Acinetobacter baumannii: A 7-Year Single Center Study.
Chromosomal mutations in GyrA contribute to fluoroquinolone resistance
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
Genome profiling of fluoroquinolone-resistant uropathogenic Escherichia coli isolates from Brazil.
Prevalence and Characterization of Quinolone-Resistance Determinants in Escherichia coli Isolated from Food-Producing Animals and Animal-Derived Food in the Philippines.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
Correlation between antibiotic resistance and phylogenetic types among multidrug-resistant Escherichia coli isolated from urinary tract infections.
Antimicrobial Resistance of Non-Typhoid Salmonella in Meat and Meat Products.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
Single mutation in 2018 S. sonnei strains, triple mutations in 2020 S. sonnei strain
Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant, qnr-Carrying Escherichia coli Isolated from the German Food Chain in 2017.
Antimicrobial Resistance and Molecular Epidemiology of Uropathogenic Escherichia coli Isolated From Female Patients in Shanghai, China.
Antimicrobial Resistance in Salmonella Typhi Isolated From a Referral Hospital of Kathmandu, Nepal.
The gyrA ser83 mutation was found in 95.65% of S. Typhi isolates.
Clones and Clusters of Antimicrobial-Resistant Klebsiella From Southwestern Nigeria.
Genomic comparisons of Escherichia coli ST131 from Australia.
Dual gyrA-1AB and parC-1aAB mutations are unique to clade C ST131 isolates but were identified in some clade A isolates.
Ciprofloxacin-resistant Gram-negative isolates from a tertiary care hospital in Eastern India with novel gyrA and parC gene mutations.
Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
Double amino acid exchange in GyrA
Wild Boars as an Indicator of Environmental Spread of ESβL-Producing Escherichia coli.
Analysis of molecular mechanisms of delafloxacin resistance in Escherichia coli.
Mutations in QRDRs are associated with delafloxacin resistance
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Escherichia coli Isolates in Suzhou, China.
Widespread dissemination of Salmonella, Escherichia coli and Campylobacter resistant to medically important antimicrobials in the poultry production continuum in Canada.
Mutations in gyrA were associated with resistance to fluoroquinolones.
Mechanisms of fluoroquinolone resistance among Escherichia coli isolates from urinary tract infections in Thailand.
Nalidixic acid-a good marker of fluoroquinolone resistance mechanisms in Escherichia coli.
Dissemination of extended-spectrum beta-lactamase-producing Escherichia coli in poultry in Zimbabwe.
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
Genomic Analysis of Antibiotic Resistance and Virulence Profiles in Escherichia coli Linked to Sternal Bursitis in Chickens: A One Health Perspective.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
Analysis of the microbial spectrum of urinary tract infections and antibiotic resistance of UPEC in Central Inner Mongolia, China.
Genomic and phenotypic characterization of antimicrobial resistance in clinical Nocardia species isolates.
Mutations in gyrA correlate with ciprofloxacin resistance
Integrative review on Acinetobacter baumannii as a multidrug-resistant pathogen: resistance mechanisms and therapeutic perspectives in the context of nosocomial infections.
Gatifloxacin activity against quinolone-resistant gyrase: allele-specific enhancement of bacteriostatic and bactericidal activities by the C-8-methoxy group.
Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease.
Mutations in gyrA were associated with nalidixic acid and ciprofloxacin resistance.
Characterization of antimicrobial-resistant Salmonella isolated from imported foods.
Nalidixic acid-resistant Salmonella enterica serotype Typhi presenting as a primary psoas abscess: case report and review of the literature.
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Pseudomonas aeruginosa in dogs and cats.
Rapid determination of quinolone resistance in Acinetobacter spp.
Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay.
Mutation in GyrA associated with reduced ciprofloxacin sensitivity.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
Pseudomonas aeruginosa: resistance to the max.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
Mutations in gyrA are often accompanied by mutations in parC.
South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study.
Identification of an NDM-5-producing Escherichia coli Sequence Type 167 in a Neonatal Patient in China.
Genetic characterization of fluoroquinolone-resistant Escherichia coli associated with bovine mastitis in India.
Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.
Mutations in gyrA gene were identified in several Enterobacteriaceae isolates.
The ST131 Escherichia coli H22 subclone from human intestinal microbiota: Comparison of genomic and phenotypic traits with those of the globally successful H30 subclone.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China.
Mutations in gyrA and parC contribute to fluoroquinolone resistance.
The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium.
Mutations in QRDR region of gyrA gene associated with enrofloxacin resistance
Profiling Virulence and Antimicrobial Resistance Markers of Enterovirulent Escherichia Coli from Fecal Isolates of Adult Patients with Enteric Infections in West Cameroon.
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India.
Mutations in gyr A contribute to fluoroquinolone resistance.
Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006-2016
The level of antimicrobial resistance of sewage isolates is higher than that of river isolates in different Escherichia coli lineages.
Selection of Resistant Bacteria in Mallards Exposed to Subinhibitory Concentrations of Ciprofloxacin in Their Water Environment.
Both mutations were shown to confer resistance to ciprofloxacin in the study.
Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling.
Epidemic and molecular characterization of fluoroquinolone-resistant Shigella dysenteriae 1 isolates from calves with diarrhea.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
Mutations in gyrA contribute to fluoroquinolone resistance.
Current Evidence for Corynebacterium on the Ocular Surface.
Mutations in gyrA contribute to fluoroquinolone resistance in Corynebacterium species.
Azithromycin and Ciprofloxacin Treatment Outcomes During an Outbreak of Multidrug-Resistant Shigella sonnei Infections in a Retirement Community-Vermont, 2018.
associated with decreased susceptibility to ciprofloxacin
Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure-Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli.
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
Molecular characterization of fluoroquinolone-resistant Escherichia coli from broiler breeder farms.
Mutations in gyrA are associated with high-level fluoroquinolone resistance.
Emergence of mcr-1-Harboring Salmonella enterica Serovar Sinstorf Type ST155 Isolated From Patients With Diarrhea in Jiangsu, China.
Mutations in gyrA contribute to ciprofloxacin resistance.
Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
Mutations in gyrA gene were detected at codon S83 or D87 or both in 89.66% of XDR Salmonella.
Optimizing Nanopore Sequencing for Rapid Detection of Microbial Species and Antimicrobial Resistance in Patients at Risk of Surgical Site Infections.
Detected in Salmonella enterica
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
Chromosomal quinolone resistance mutations in gyrA
Research note: The resistome of commensal Escherichia coli isolated from broiler carcasses "produced without the use of antibiotics"(a).
Draft Genome Sequence of a Uropathogenic Escherichia coli Sequence Type 44 Strain Carrying Multiple Antimicrobial Resistance Genes.
Virulome and genome analyses identify associations between antimicrobial resistance genes and virulence factors in highly drug-resistant Escherichia coli isolated from veal calves.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
Genomic perspective on the bacillus causing paratyphoid B fever.
Mutations in quinolone resistance-determining regions of gyrA and gyrB
Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
mutation in QRDR region
Brief antibiotic use drives human gut bacteria towards low-cost resistance.
Mutations in gyrA were found to occur de novo within the gut and persist long after antibiotic exposure, with no measurable fitness cost.
Genomic insights into antimicrobial resistance and virulence of E. coli in central Ethiopia: a one health approach.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
Confers resistance to fluoroquinolones.
Genomic snapshot of Klebsiella spp. isolates from clinically ill animals reveal diverse lineages with limited relatedness to human isolates.
Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance.
Anthropogenic contamination sources drive differences in antimicrobial-resistant Escherichia coli in three urban lakes.
The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli.
Mutations in gyrA, such as S83L and D87G, reduce susceptibility to fluoroquinolones, contributing to ciprofloxacin resistance.
Mutations in GyrA are associated with fluoroquinolone resistance, leading to reduced susceptibility to ciprofloxacin.
An Rcs Stress-Based High-Throughput Screen Reveals Novel Gyrase Inhibitors as Indirect Inducers of Cell Envelope Stress in Gram-Negative Bacteria.
Mutation in gyrA conferring resistance to fluoroquinolones
Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
Characteristics of quinolone resistance in Escherichia coli isolated from wildlife in Poland.
Mutations in QRDR region are associated with high MIC values
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
Genomic Insights into bla(NDM-5)-Producing Escherichia coli ST648 Isolates from Human and Wildlife Sources in Lebanon.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
Mutations in gyrA contribute to fluoroquinolone resistance
Antibiotic resistance determinants of a group of multidrug-resistant Acinetobacter baumannii in China.
mutation in QRDR of gyrA
Draft Genome Sequences of Antibiotic-Resistant Commensal Escherichia coli.
Strain CS05 shows resistance to nalidixic acid due to mutations in gyrA.
Phenotypic and molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli in Bangladesh.
Prediction of resistance development against drug combinations by collateral responses to component drugs.
The emergence of the 16S rRNA methyltransferase RmtB in a multidrug-resistant Serratia marcescens isolate in China.
Molecular epidemiology and genetic diversity of fluoroquinolone-resistant Escherichia coli isolates from patients with community-onset infections in 30 Chinese county hospitals.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
Activity of ceftazidime-avibactam against fluoroquinolone-resistant Enterobacteriaceae and Pseudomonas aeruginosa.
Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
Comparative analysis of quinolone resistance in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese children and adults.
Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to India.
Mutation in gyrA gene associated with ciprofloxacin resistance in Shigella sonnei.
Enhanced resistance to fluoroquinolones in laboratory-grown mutants & clinical isolates of Shigella due to synergism between efflux pump expression & mutations in quinolone resistance determining region.
Mutations in QRDR of gyrA contribute to fluoroquinolone resistance
Emergence and spread of O16-ST131 and O25b-ST131 clones among faecal CTX-M-producing Escherichia coli in healthy individuals in Hunan Province, China.
gyrA 1A
'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites.
The gyrA-R237H mutation was strongly associated with HR isolates.
Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, Republic of Korea.
Mutation GyrA(S83L)
Prevalence and molecular characterization of multi-resistant Escherichia coli isolates from clinical bovine mastitis in China.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
Found in S. enterica isolate SE01
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
Association between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance.
Efficacy of Ciprofloxacin for Treatment of Cholera Associated with Diminished Susceptibility to Ciprofloxacin to Vibrio cholerae O1.
Mutation in gyrA gene associated with decreased susceptibility to ciprofloxacin.
Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.
Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India.
Molecular characterization of multidrug-resistant Klebsiella pneumoniae isolates.
Fluoroquinolone-Resistant Enteric Bacteria in Sub-Saharan Africa: Clones, Implications and Research Needs.
Mutations in QRDR of gyrA and parC contribute to fluoroquinolone resistance.
Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility.
Mutations in gyrA are associated with fluoroquinolone resistance.
Antimicrobial Resistance Mechanisms
Plasmid-mediated fluoroquinolone resistance associated with extra-intestinal Escherichia coli isolates from hospital samples.
Salmonellosis detection and evidence of antibiotic resistance in an urban raccoon population in a highly populated area, Costa Rica.
Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study.
Detected in one patient (ID 512) under ciprofloxacin treatment.
A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii.
Detected in 45 out of 47 FQ-resistant strains
Rapid Detection of Genetic Engineering, Structural Variation, and Antimicrobial Resistance Markers in Bacterial Biothreat Pathogens by Nanopore Sequencing.
Mutation in the quinolone resistance-determining region
Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018.
Antimicrobial susceptibility pattern of Acinetobacter isolates from patients in Kenyatta National Hospital, Nairobi, Kenya.
Prevalence of Quinolone Resistance of Extended-Spectrum β-Lactamase-Producing Escherichia coli with ST131-fimH30 in a City Hospital in Hyogo, Japan.
Genomic Epidemiology of Major Extraintestinal Pathogenic Escherichia coli Lineages Causing Urinary Tract Infections in Young Women Across Canada.
Mutations in gyrA and parC confer quinolone resistance.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
Mutations in gyrA contribute to fluoroquinolone resistance.
Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs.
Genomic Characterization of Prevalent mcr-1, mcr-4, and mcr-5 Escherichia coli Within Swine Enteric Colibacillosis in Spain.
Etiology of childhood diarrhoea among under five children and molecular analysis of antibiotic resistance in isolated enteric bacterial pathogens from a tertiary care hospital, Eastern Odisha, India.
A Comprehensive Account of Escherichia coli Sequence Type 131 in Wastewater Reveals an Abundance of Fluoroquinolone-Resistant Clade A Strains.
Mutations in gyrA were identified in clade A strains, contributing to fluoroquinolone resistance.
Antibiotic Resistance Among Uropathogenic Escherichia coli.
Prevalence of fluoroquinolone-resistant Salmonella serotypes in Iran: a meta-analysis.
Mutations in gyrA were detected in nalidixic acid-resistant isolates.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
Mutations in quinolone resistance-determining region
Genomic Characterization of Antibiotic Resistant Escherichia coli Isolated From Domestic Chickens in Pakistan.
Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring bla(NDM-1), mcr-1, and fosA3 from a patient in China.
An investigation of the presence and antimicrobial susceptibility of Enterobacteriaceae in raw and cooked kibble diets for dogs in the United Kingdom.
Fluoroquinolone resistance in complicated urinary tract infections: association with the increased occurrence and diversity of Escherichia coli of clonal complex 131, together with ST1193.
Mutations associated with fluoroquinolone resistance
Development of an in vitro biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota.
A novel variant in Salmonella genomic island 1 of multidrug-resistant Salmonella enterica serovar Kentucky ST198.
Mutations in the quinolone resistance-determining region (QRDR) of gyrA.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
Resistance to Fluoroquinolone by a Combination of Efflux and Target Site Mutations in Enteroaggregative Escherichia coli Isolated in Korea.
common mutation
Short reads-based characterization of pathotype diversity and drug resistance among Escherichia coli isolated from patients attending regional referral hospitals in Tanzania.
Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK.
Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model.
Mutation in gyrA was associated with increased MIC for ciprofloxacin.
Ciprofloxacin-resistant Salmonella typhi in the UK.
Chromosomal resistance to ciprofloxacin was observed in multiresistant S. typhi strains.
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy domestic cats.
Resistance to quinolones in mycobacteria
Mutations in gyrA are associated with quinolone resistance in mycobacteria.
Multiplex Real-Time Polymerase Chain Reaction-Based Method for the Rapid Detection of gyrA and parC Mutations in Quinolone-Resistant Escherichia coli and Shigella spp.
Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro.
Genomic portrait of the evolution and epidemic spread of a recently emerged multidrug-resistant Shigella flexneri clone in China.
Study of Mutations in the DNA gyrase gyrA Gene of Escherichia coli.
Mutations in gyrA contribute to ciprofloxacin resistance in E. coli.
Fitness cost associated with resistance to fluoroquinolones is diverse across clones of Klebsiella pneumoniae and may select for CTX-M-15 type extended-spectrum β-lactamase.
Molecular characterization and PCR-based replicon typing of multidrug resistant Shigella sonnei isolates from an outbreak in Thimphu, Bhutan.
Quinolone resistance mechanisms among extended-spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from rivers and lakes in Switzerland.
Fluoroquinolone resistance mechanisms of Shigella flexneri isolated in Bangladesh.
Mutations in gyrA contribute to fluoroquinolone resistance
An outbreak of blaOXA-51-like- and blaOXA-66-positive Acinetobacter baumannii ST208 in the emergency intensive care unit.
Mutations in gyrA contribute to quinolone resistance
Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network.
mutation in DNA gyrase subunit A
Dynamics of quinolone resistance in fecal Escherichia coli of finishing pigs after ciprofloxacin administration.
Comparative genomics of Serratia marcescens strains SM39 and Db11
Mutation in the quinolone resistance-determining region
High levels of multiresistance in quinolone resistant urinary tract isolates of Escherichia coli from Norway; a non clonal phenomenon?
Mutations in gyrA were associated with quinolone resistance.
Epidemiology and molecular characterization of multidrug-resistant Escherichia coli isolates harboring bla(CTX-M) group 1 extended-spectrum β-lactamases causing bacteremia and urinary tract infection in Manhiça, Mozambique.
Antimicrobial Resistance in Acinetobacter spp. and Pseudomonas spp.
Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
Mutations in gyrA contribute to quinolone resistance.
Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.
Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery.
Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana.
Failure of Ciprofloxacin Therapy in the Treatment of Community-Acquired Acute Pyelonephitis caused by In-Vitro Susceptible Escherichia coli Strain Producing CTX-Type Extended-Spectrum β-Lactamase.
Single point mutation in quinolone resistance-determining regions
Continuous culture of Escherichia coli, under selective pressure by a novel antimicrobial complex, does not result in development of resistance.
This mutation was observed in the LVX-exposed population and is associated with levofloxacin resistance.
Resistance and Virulence Mechanisms of Escherichia coli Selected by Enrofloxacin in Chicken
Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes.
Genomic epidemiology of severe community-onset Acinetobacter baumannii infection.
High prevalence of fluoroquinolone-resistant Escherichia coli strains isolated from urine clinical samples.
Nosocomial infection by sequence type 357 multidrug-resistant Acinetobacter baumannii isolates in a neonatal intensive care unit in Daejeon, Korea.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
GyrA S83L mutation confers resistance to ciprofloxacin.
Clinically relevant mutant DNA gyrase alters supercoiling, changes the transcriptome, and confers multidrug resistance.
The Asp87Gly mutation in gyrA leads to reduced susceptibility to multiple antibiotics.
Bacterial resistance studies using in vitro dynamic models: the predictive power of the mutant prevention and minimum inhibitory antibiotic concentrations.
Single nucleotide substitution in the quinolone-resistance determining region (QRDR) of gyrA
Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and bla(NDM) gene in Enterobacteriaceae causing neonatal septicaemia.
Mutations in gyrA contribute to fluoroquinolone resistance.
Association of fluoroquinolone resistance, virulence genes, and IncF plasmids with extended-spectrum-β-lactamase-producing Escherichia coli sequence type 131 (ST131) and ST405 clonal groups.
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli.
Mutations in gyrA were observed in wild-type E. coli adapted to enrofloxacin.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
A survey of antimicrobial-resistant Escherichia coli prevalence in wild mammals in Japan using antimicrobial-containing media.
Non-lactose fermenting Escherichia coli: Following in the footsteps of lactose fermenting E. coli high-risk clones.
A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.
associated with reduced susceptibility to fluoroquinolones
Prevalence and whole genome phylogenetic analysis reveal genetic relatedness between antibiotic resistance Salmonella in hatchlings and older chickens from farms in Nigeria.
The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic.
Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes in Salmonella and Shigella isolated from clinical specimens in Thailand.
Rapid emergence of extensively drug-resistant Shigella sonnei in France.
Study on the drug resistance and pathogenicity of Escherichia coli isolated from calf diarrhea and the distribution of virulence genes and antimicrobial resistance genes.
One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
Mutations in gyrA contribute to fluoroquinolone resistance.
Horizontal Gene Transfer, Fitness Costs and Mobility Shape the Spread of Antibiotic Resistance Genes into Experimental Populations of Acinetobacter Baylyi.
Role of the Water-Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase.
Wild-type GyrA is susceptible to quinolones
Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae.
Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
Single substitution
Fluoroquinolone resistance among fecal extended spectrum βeta lactamases positive Enterobacterales isolates from children in Dar es Salaam, Tanzania.
Discovery of a novel sub-lineage of multi-drug resistant Shigella flexneri in Southern California.
chromosomal mutation
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
Mutations in QRDR of gyrA and parC were found in all ciproR-E. coli.
Genomic characterization of endemic diarrheagenic Escherichia coli and Escherichia albertii from infants with diarrhea in Vietnam.
Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study.
The Prevalence of Multidrug-Resistant Enterobacteriaceae among Neonates in Kuwait.
Prevalence and Characterization of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Dogs and Cats in South Korea.
Assessment of Prevalence and Diversity of Antimicrobial Resistant Escherichia coli from Retail Meats in Southern California.
Genomic Characterization of Uropathogenic Escherichia coli Isolates from Tertiary Hospitals in Riyadh, Saudi Arabia.
Investigation of Delafloxacin Resistance in Multidrug-Resistant Escherichia coli Strains and the Detection of E. coli ST43 International High-Risk Clone.
mutations in QRDR of gyrA contribute to fluoroquinolone resistance
Expansion of healthcare-associated hypervirulent KPC-2-producing Klebsiella pneumoniae ST11/KL64 beyond hospital settings.
Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals.
Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs.
Multidrug Resistance Profiles and Resistance Mechanisms to β-Lactams and Fluoroquinolones in Bacterial Isolates from Hospital Wastewater in Bangladesh.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
Increase in the community circulation of ciprofloxacin-resistant Escherichia coli despite reduction in antibiotic prescriptions.
Corrigendum: Pathogen genomics and phage-based solutions for accurately identifying and controlling Salmonella pathogens.
Evolution of antimicrobial resistance in E. coli biofilm treated with high doses of ciprofloxacin.
Development of Cas13a-based assays for Neisseria gonorrhoeae detection and gyrase A determination.
The mutation in gyrA at codon 91 (Ser83Leu) was identified as responsible for ciprofloxacin resistance.
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis.
Occurrence of a New Variant of Salmonella Infantis Lacking Somatic Antigen.
Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes.
One of the most frequent mutations in E. coli
Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022.
All isolates had this mutation
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
Economic evaluation of antimicrobial resistance in curable sexually transmitted infections; a systematic review and a case study.
Mutation in gyrA gene associated with ciprofloxacin resistance
Strain belonging to an emerging, virulent sublineage of ST131 Escherichia coli isolated in fresh spinach, suggesting that ST131 may be transmissible through agricultural products.
Resistance development in Escherichia coli to delafloxacin at pHs 6.0 and 7.3 compared to ciprofloxacin.
Mutations in gyrA were seen in all derivatives challenged with CIP, regardless of pH.
The clinical, genomic, and microbiological profile of invasive multi-drug resistant Escherichia coli in a major teaching hospital in the United Kingdom.
Mutations in gyrA contribute to ciprofloxacin resistance.
Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand.
most common mutation
Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance.
Distribution of Extended-Spectrum-β-Lactamase-Producing Diarrheagenic Escherichia coli Clonal Complex 10 Isolates from Patients with Diarrhea in the Republic of Korea.
Genome Analysis of Klebsiella pneumoniae Reveals International High-Risk Pandemic MDR Clones Emerging in Tertiary Healthcare Settings in Uganda.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
Mutations in gyrA contribute to fluoroquinolone resistance.
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
Empirical use of ciprofloxacin for acute uncomplicated pyelonephritis caused by Escherichia coli in communities where the prevalence of fluoroquinolone resistance is high.
Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain.
The Ser83Leu mutation in the gyrA gene is associated with quinolone resistance.
Frequency and factors associated with carriage of multi-drug resistant commensal Escherichia coli among women attending antenatal clinics in central India.
Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico.
Mutations in the quinolone-resistance determining regions of gyrA and parC genes
Temporal changes in resistance mechanisms in colonizing Escherichia coli isolates with reduced susceptibility to fluoroquinolones.
Characterization and comparison of extended-spectrum β-lactamase (ESBL) resistance genotypes and population structure of Escherichia coli isolated from Franklin's gulls (Leucophaeus pipixcan) and humans in Chile.
Mutations in gyrA were found in avian ESBL isolates.
Susceptibility to β-lactams and quinolones of Enterobacteriaceae isolated from urinary tract infections in outpatients.
Comparative Genomics of Two ST 195 Carbapenem-Resistant Acinetobacter baumannii with Different Susceptibility to Polymyxin Revealed Underlying Resistance Mechanism.
Mutations in gyrA contribute to fluoroquinolone resistance.
Implementation of Whole Genome Sequencing (WGS) for Identification and Characterization of Shiga Toxin-Producing Escherichia coli (STEC) in the United States.
Mutations in gyrA alone or in combination with mutations in parC confer resistance to nalidixic acid and ciprofloxacin.
Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.
Genome Sequence of Kocuria polaris Strain CD08_4, an Isolate from the Duodenal Mucosa of a Celiac Disease Patient.
Analytical profiling of mutations in quinolone resistance determining region of gyrA gene among UPEC.
Mutations in the QRDR of gyrA are strongly associated with quinolone resistance in UPEC.
Comparative genomics identifies distinct lineages of S. Enteritidis from Queensland, Australia.
associated with reduced susceptibility to quinolones
Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.
The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure.
Out of Asia: the independent rise and global spread of fluoroquinolone-resistant Shigella.
mutations in QRDR region of gyrA and parC are primarily responsible for fluoroquinolone resistance in Shigella
Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.
High Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Among Clinical Isolates From Cats and Dogs Admitted to a Veterinary Hospital in Switzerland.
Pathogenic potential and the role of clones and plasmids in beta-lactamase-producing E. coli from chicken faeces in Vietnam.
Mutations in the quinolone resistance-determining region (QRDR) of gyrA and parC genes.
Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.
Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
Mutations in gyrA and parC are associated with fluoroquinolone resistance in various bacterial species.
Zinc can counteract selection for ciprofloxacin resistance.
Spontaneously mutated ciprofloxacin-resistant strain was created through serial inoculation of overnight culture in LB medium supplemented with incremental concentrations of ciprofloxacin.
Molecular characterization of quinolone resistant Shigella spp. isolates from patients in Ardabil, Iran.
Emergence of CTX-M-27-producing Escherichia coli of ST131 and clade C1-M27 in an impacted ecosystem with international maritime traffic in South America.
Plasmid-Mediated Colistin Resistance (mcr-1) in Escherichia coli from Non-Imported Fresh Vegetables for Human Consumption in Portugal.
chromosomal point mutation
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
Non-synonymous mutation at amino acid 83 in gyrA correlates with quinolone resistance.
Predictable properties of fitness landscapes induced by adaptational tradeoffs.
The Genome Structure of Ciprofloxacin-Resistant Mycoplasma Hominis Clinical Isolates.
Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
Comparative Genome Analyses of Wild Type- and Quinolone Resistant Escherichia coli Indicate Dissemination of QREC in the Norwegian Broiler Breeding Pyramid.
Detection of Ciprofloxacin-Resistant, β-Lactamase-Producing Neisseria meningitidis Serogroup Y Isolates - United States, 2019-2020.
associated with ciprofloxacin resistance
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes.
associated with high-level ciprofloxacin resistance
Bird-livestock interactions associated with increased cattle fecal shedding of ciprofloxacin-resistant Escherichia coli within feedlots in the United States.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
found in E. coli strains
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
Transferable Extended-Spectrum β-Lactamase (ESBL) Plasmids in Enterobacteriaceae from Irrigation Water.
Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens.
The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.
Mutations in the QRDR region
Profiles of gyrA Mutations and Plasmid-Mediated Quinolone Resistance Genes in Shigella Isolates with Different Levels of Fluoroquinolone Susceptibility.
Present in ciprofloxacin-intermediate and ciprofloxacin-resistant isolates.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Detected in isolate C1722
Complete Genome Assembly of a Multidrug-Resistant New Delhi Metallo-β-Lactamase 1 (NDM-1)-Producing Escherichia coli Human Isolate from a New Zealand Hospital.
Design and Evaluation of Novel Fluoroquinolone Analogues Against Resistant E. coli
Mutations in GyrA contribute to fluoroquinolone resistance in E. coli.
Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance.
Mutation in gyrA was identified as the resistance mechanism in PA01 after exposure to sub-MIC of OFL.
Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains.
Genome Analysis of ESBL-Producing Escherichia coli Isolated from Pigs.
Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
Prevalence of Plasmid-Mediated Quinolone Resistance (PMQRs) Determinants and Whole Genome Sequence Screening of PMQR-Producing E. coli Isolated from Men Undergoing a Transrectal Prostate Biopsy.
Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020.
Investigation of In Vitro Susceptibility and Resistance Mechanisms in Skin Pathogens: Perspectives for Fluoroquinolone Therapy in Canine Pyoderma.
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
Antimicrobial resistance and genomic investigation of non-typhoidal Salmonella isolated from outpatients in Shaoxing city, China.
Single and double mutations in the gene gyrA were observed
Whole genome sequence analysis of ESBL-producing Escherichia coli recovered from New Zealand freshwater sites.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria.
Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel.
Point mutation in quinolone-resistance determining region
Linking epidemiological and genomic data in cases of enteric fever in England to inform clinical management and public health action.
Mutations in gyrA confer resistance to ciprofloxacin.
Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.
Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients.
The Prevalence of Multidrug-Resistant Escherichia coli in Chennai and Whole Genome Sequence Analysis of Carbapenem-Resistant Escherichia coli ST410.
A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease.
Evolution of ciprofloxacin resistance in Salmonella Typhimurium and its impact on virulence and colonization
Mutations identified in the quinolone resistance-determining regions
Omadacycline is active in vitro and in vivo against ciprofloxacin-resistant Bacillus anthracis.
The gyrA mutation (Ser83Leu) was identified in the ciprofloxacin-resistant BAC r 4-2 strain.
Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.
gyrA
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.
Escherichia coli gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003294
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
Under development. Phenotype should be used with caution.
Molecular screening for Neisseria gonorrhoeae antimicrobial resistance markers in Nigerian men who have sex with men and transgender women.
Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
Mutations in gyrA contribute to fluoroquinolone resistance in S. pneumoniae.
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