ResLit - Antimicrobial Resistance Gene & Mutation Database

Nucleotide ChangeA2C

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: ceftazidime|piperacillin-tazobactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.

PMID 10639363 · 2000

The A→C change in the second position of the −10 region of the blaSHV-1 promoter leads to reduced β-lactamase expression and lower resistance.

Mutation Information

blaSHV-1: c.A2C

Nucleotide Change: A2C
Organisms: Klebsiella pneumoniae
Confers Resistance To: ceftazidime|piperacillin-tazobactam
Source Database: Reslit

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