GenepenA
Protein ChangeA501V
Validation StatusCandidate
Databases
Reslit
Overview
- Mechanism
- increased resistance
- Resistance To
- cefixime|ceftriaxone, ceftriaxone|cefixime
- Organisms
- Neisseria gonorrhoeae
- Papers
- 2
Paper Information2
1
Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone.
PenA mutations including deletion of A leading to Ala-501→Val substitution are associated with reduced susceptibility to cefixime and ceftriaxone.
Mutation Information
- Protein Change
- A501V
- Organisms
- Neisseria gonorrhoeae
- Confers Resistance To
- cefixime|ceftriaxone
- Source Database
- Reslit
2
Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.
Mutations in penA are critical for intermediate resistance to expanded-spectrum cephalosporins in Neisseria gonorrhoeae.
Mutation Information
- Protein Change
- A501V
- Organisms
- Neisseria gonorrhoeae
- Confers Resistance To
- ceftriaxone|cefixime
- Effect on Function
- increased resistance
- Source Database
- Reslit
Comments (0)
No comments yet. Be the first to comment!