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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations uhpBG469R

GeneuhpB

kinase of the two-component response regulator (UhpA) required for uhpT expression

Protein ChangeG469R

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of G6P-mediated induction of uhpT expression
Resistance To: Fosfomycin
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Novel Chromosomal Mutations Responsible for Fosfomycin Resistance in Escherichia coli.

PMID 33193186 · 2020

The mutation G469R in uhpB was associated with a 128-fold increase in fosfomycin MICs and conferred resistance.

Mutation Information

Protein Change: G469R
Organisms: Escherichia coli
Confers Resistance To: Fosfomycin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

disruption of G6P-mediated induction of uhpT expression

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research