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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations tolCR453S

GenetolC

outer membrane factor

Protein ChangeR453S

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Ciprofloxacin|Doxycycline|Chloramphenicol
Organisms: Francisella tularensis, Francisella novicida
Papers: 1

Paper Information1

1

Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.

PMID 33193267 · 2020

Mutations in tolC are associated with ciprofloxacin resistance.

Mutation Information

Protein Change: R453S
Organisms: Francisella tularensis, Francisella novicida
Confers Resistance To: Ciprofloxacin|Doxycycline|Chloramphenicol

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Source Database

Reslit

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research