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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations panDE126A

GenepanD

aspartate decarboxylase

Protein ChangeE126A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased enzyme activity
Resistance To: Pyrazinamide
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.

PMID 33984234 · 2021

All mutations were identified in PZA/POA-resistant Mtb strains.

Mutation Information

Protein Change: E126A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Pyrazinamide

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

decreased enzyme activity

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research