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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations oqxBR157A

GeneoqxB

efflux pump

Protein ChangeR157A

Nucleotide ChangeC470A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced efflux liability for fluoroquinolone molecules
Resistance To: Fluoroquinolones
Organisms: Klebsiella pneumoniae, Escherichia coli, Salmonella spp., Enterobacter cloacae
Papers: 1

Paper Information1

1

Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.

PMID 34518546 · 2021

Point mutation of R157A reduced efflux liability for fluoroquinolone molecules as predicted

Mutation Information

oqxB: p.R157A / c.C470A

Protein Change: R157A
Nucleotide Change: C470A
Organisms: Klebsiella pneumoniae, Escherichia coli, Salmonella spp., Enterobacter cloacae

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Confers Resistance To

Fluoroquinolones

Effect on Function

reduced efflux liability for fluoroquinolone molecules

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research