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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations Rv2172cL214A

5,10-methylenetetrahydrofolate reductase

Protein ChangeL214A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased methionine production
Resistance To: Para-aminosalicylic acid
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis.

PMID 34780266 · 2022

Mutations in rv2172c lead to decreased methionine production and increased susceptibility to PAS.

Mutation Information

Rv2172c: p.L214A

Protein Change: L214A
Organisms: Mycobacterium tuberculosis
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Para-aminosalicylic acid

Effect on Function

decreased methionine production

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research