Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System.
The wild-type PhoP protein is part of the PhoPQ regulatory system that activates pmrHFIJKLM expression responsible for l-aminoarabinose synthesis and polymyxin resistance.
phoP
Klebsiella mutant PhoP conferring antibiotic resistance to colistin; CARD accession: CARD:3003585
A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility.
Mutations in PhoP/PhoQ lead to constitutive activation of the arnBCADTEF operon and pmrC.
Antibiotic Heteroresistance in Klebsiella pneumoniae.
Mutations in PhoP are associated with colistin heteroresistance.
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.
Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.
Specific mutations in PhoPQ were found to activate arn operon transcription and confer colistin resistance.
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