gyrA

Overview

Drug Classes
Ciprofloxacin, fluoroquinolones, ciprofloxacin, clinafloxacin|ciprofloxacin|trovafloxacin, Nalidixic acid, Nalidixic acid,Ciprofloxacin, norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin, levofloxacin, ofloxacin|ciprofloxacin|trovafloxacin|sparfloxacin, quinolones, norfloxacin|ciprofloxacin, levofloxacin|clinafloxacin, moxifloxacin, ciprofloxacin|levofloxacin|moxifloxacin|clinafloxacin, ciprofloxacin|ofloxacin|nalidixic acid, Ciprofloxacin|Moxifloxacin, ciprofloxacin|garenoxacin, ofloxacin, nalidixic acid, nalidixic acid|ciprofloxacin, ciprofloxacin|levofloxacin|moxifloxacin, ciprofloxacin|nalidixic acid, ciprofloxacin|levofloxacin, ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin, ciprofloxacin|norfloxacin, gemifloxacin|trovafloxacin|sparfloxacin|ciprofloxacin, norfloxacin, ciprofloxacin|gatifloxacin|levofloxacin|ofloxacin, enrofloxacin, ciprofloxacin|levofloxacin|gatifloxacin, ciprofloxacin|levofloxacin|moxifloxacin|gatifloxacin|gemifloxacin|garenoxacin|norfloxacin, moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacin, ciprofloxacin|moxifloxacin|levofloxacin, moxifloxacin|levofloxacin, moxifloxacin|levofloxacin|gemifloxacin, nalidixic acid|oxolinic acid|fluoroquinolones, Nalidixic acid, Ciprofloxacin, levofloxacin|moxifloxacin|ciprofloxacin, ciprofloxacin|ofloxacin, moxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin, quinolone
Organisms
Klebsiella pneumoniae, Mycobacterium bovis, Vibrio parahaemolyticus +44 more
Papers
128
Mutations
446
Mutations446
Nucleotide ChangeProtein ChangeTypeEffect on FunctionResistance ToYearPaperStatus
-D87N--
Ciprofloxacin
2012

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID: 22633335
Not Validated
-A90V--
fluoroquinolones
1999

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.

PMID: 10049284
Not Validated
-S83I--
ciprofloxacin
1999

Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.

PMID: 10223929
Not Validated
-S84L--
ciprofloxacin
1999

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID: 10390214
Not Validated
-S84L--
ciprofloxacin
1999

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID: 10390214
Not Validated
-S84L--
ciprofloxacin
1999

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID: 10390214
Not Validated
-S84L--
ciprofloxacin
1999

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID: 10390214
Not Validated
-S83Y--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S83Y--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S83F--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S83F--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87N--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87N--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87N--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87G--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87H--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S83F--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S89F--
fluoroquinolones
1999

Fluoroquinolone resistance in Bacteroides fragilis following sparfloxacin exposure.

PMID: 10471574
Not Validated
-S81Y--
clinafloxacin|ciprofloxacin|trovafloxacin
2000

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID: 10991854
Not Validated
-D87H-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87V-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-Q106H-Target modification
Nalidixic acid,Ciprofloxacin
1976

Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.

PMID: 185097
Not Validated
-S83A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-A84V-Target modification
Nalidixic acid,Ciprofloxacin
2001

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID: 11451702
Not Validated
-D87G-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87H-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-Q106R-Target modification
Nalidixic acid,Ciprofloxacin
1976

Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.

PMID: 185097
Not Validated
-D87N-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87A-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A--
Ciprofloxacin
2012

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID: 22633335
Not Validated
-D87G--
Ciprofloxacin
2012

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID: 22633335
Not Validated
-S83L--
Ciprofloxacin
2012

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID: 22633335
Not Validated
-S83F--
Ciprofloxacin
2012

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID: 22633335
Not Validated
-A90V--
fluoroquinolones
1999

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.

PMID: 10049284
Not Validated
-Y100D--
norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin
2002

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

PMID: 12121955
Not Validated
-S81F--
levofloxacin
2003

Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America.

PMID: 12791865
Not Validated
-S83I--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-D87G--
ofloxacin|ciprofloxacin|trovafloxacin|sparfloxacin
2000

Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.

PMID: 10602715
Not Validated
-S81F--
clinafloxacin|ciprofloxacin|trovafloxacin
2000

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID: 10991854
Not Validated
-S84L--
quinolones
2001

Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.

PMID: 11709337
Not Validated
-S83I--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S81L--
clinafloxacin|ciprofloxacin|trovafloxacin
2000

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID: 10991854
Not Validated
-D87Y--
ciprofloxacin
1999

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID: 10428935
Not Validated
-S81F--
clinafloxacin|ciprofloxacin|trovafloxacin
2000

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID: 10991854
Not Validated
-T86I--
fluoroquinolones
2001

Antimicrobial resistance and bacterial identification utilizing a microelectronic chip array.

PMID: 11230433
Not Validated
-S84L--
fluoroquinolones
2002

Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.

PMID: 11751133
Not Validated
-S83L-mutations in gyrA confer resistance to fluoroquinolones
norfloxacin|ciprofloxacin
2003

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

PMID: 14506034
Not Validated
-D95N--
ciprofloxacin
2000

An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones.

PMID: 10799008
Not Validated
-S81F--
levofloxacin|clinafloxacin
2000

Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae.

PMID: 11036007
Not Validated
-T83I--
moxifloxacin
2001

Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.

PMID: 11451695
Not Validated
-S83I--
norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin
2002

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

PMID: 12121955
Not Validated
-S84L-reduced potency of ciprofloxacin
quinolones
2001

Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.

PMID: 11257024
Not Validated
-S82L--
ciprofloxacin|levofloxacin|moxifloxacin|clinafloxacin
2001

gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains.

PMID: 11408211
Not Validated
-S85P--
ciprofloxacin
2001

Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.

PMID: 11600359
Not Validated
-E85K--
levofloxacin
2003

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID: 12878509
Not Validated
-S83L--
ciprofloxacin|ofloxacin|nalidixic acid
2001

Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.

PMID: 11600360
Not Validated
-D71V--
Ciprofloxacin|Moxifloxacin
2002

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID: 12384345
Not Validated
-E85K--
levofloxacin
2003

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID: 12878509
Not Validated
-T83I--
ciprofloxacin|garenoxacin
2005

Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.

PMID: 15917569
Not Validated
-S95T--
ofloxacin
2002

Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.

PMID: 11796356
Not Validated
-T82I--
Ciprofloxacin|Moxifloxacin
2002

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID: 12384345
Not Validated
-P162T--
levofloxacin
2003

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID: 12878509
Not Validated
-S83L--
nalidixic acid
2001

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.

PMID: 11699598
Not Validated
-A118T--
Ciprofloxacin|Moxifloxacin
2002

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID: 12384345
Not Validated
-L83F--
nalidixic acid|ciprofloxacin
2002

A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.

PMID: 12450802
Not Validated
-P162T--
levofloxacin
2003

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID: 12878509
Not Validated
-D107E--
nalidixic acid
2001

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.

PMID: 11699598
Not Validated
-L83F--
nalidixic acid|ciprofloxacin
2002

A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.

PMID: 12450802
Not Validated
-S83F--
ciprofloxacin
2003

Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.

PMID: 14718091
Not Validated
-S83F--
ciprofloxacin
2004

Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003.

PMID: 15498176
Not Validated
-S87V--
ciprofloxacin|levofloxacin|moxifloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-T83I--
ciprofloxacin
2003

Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis.

PMID: 14507757
Not Validated
-S83F--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-S83F--
ciprofloxacin
2004

Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.

PMID: 15380025
Not Validated
-T86I--
ciprofloxacin|nalidixic acid
2005

Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.

PMID: 15673754
Not Validated
-S83F--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-S83F--
ciprofloxacin
2004

Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.

PMID: 15380025
Not Validated
-T86I--
ciprofloxacin|nalidixic acid
2005

Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.

PMID: 15673754
Not Validated
-D87G--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-S91F--
fluoroquinolones
2004

Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.

PMID: 15243093
Not Validated
-S83L--
ciprofloxacin
2005

Isolation and molecular characterization of fluoroquinolone-resistant Escherichia coli from poultry litter.

PMID: 15685943
Not Validated
-D91Y--
ciprofloxacin|levofloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-D83N--
ciprofloxacin
2003

Ciprofloxacin treatment failure in typhoid fever case, Pakistan.

PMID: 14720407
Not Validated
-D87G--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-S83L--
ciprofloxacin
2004

Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.

PMID: 15388428
Not Validated
-S87R--
ciprofloxacin|levofloxacin|moxifloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-S81Y--
ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin
2004

Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

PMID: 14982762
Not Validated
-D87N--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-S83I--
ciprofloxacin|norfloxacin
2004

An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.

PMID: 15567276
Not Validated
-S81Y--
gemifloxacin|trovafloxacin|sparfloxacin|ciprofloxacin
2005

Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

PMID: 15728901
Not Validated
-S87R--
ciprofloxacin|levofloxacin|moxifloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-A119E--
norfloxacin
2005

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.

PMID: 15917531
Not Validated
-S83L--
nalidixic acid|ciprofloxacin
2004

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID: 14706091
Not Validated
-D87N--
ciprofloxacin
2004

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID: 15078598
Not Validated
-A88P--
ciprofloxacin|levofloxacin|moxifloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-S87F--
ciprofloxacin|levofloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-S81F--
ciprofloxacin|levofloxacin|moxifloxacin
2004

Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates.

PMID: 15388458
Not Validated
-A88P--
ciprofloxacin|levofloxacin|moxifloxacin
2005

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID: 15855486
Not Validated
-S91F--
ciprofloxacin|gatifloxacin|levofloxacin|ofloxacin
2005

Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones.

PMID: 16145072
Not Validated
-S81F--
fluoroquinolones
2003

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID: 16189113
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-S83L-likely ascribed to the previously characterized mutation occurring in the gyrA gene, with a substitution of Ser for Leu at position 83 of its amino acid sequence
fluoroquinolones
2008

Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.

PMID: 18411315
Not Validated
-D87N--
ciprofloxacin
2005

Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.

PMID: 15963294
Not Validated
-E85K--
fluoroquinolones
2003

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID: 16189113
Not Validated
-S83R--
ciprofloxacin
2006

High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.

PMID: 16517894
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-S84L--
enrofloxacin
2008

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID: 18305127
Not Validated
-S84L--
ciprofloxacin|levofloxacin|gatifloxacin
2008

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID: 18443108
Not Validated
-S83F--
ciprofloxacin|nalidixic acid
2006

Fluoroquinolone-resistant Salmonella sp. in carcasses.

PMID: 17080579
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-E88G--
enrofloxacin
2008

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID: 18305127
Not Validated
-S83F--
ciprofloxacin|nalidixic acid
2005

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID: 16207965
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-Q611L--
enrofloxacin
2008

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID: 18305127
Not Validated
-S81I--
ciprofloxacin|levofloxacin|moxifloxacin|gatifloxacin|gemifloxacin|garenoxacin|norfloxacin
2005

Novel Ser79Leu and Ser81Ile Substitutions in the Quinolone Resistance-Determining Regions of ParC Topoisomerase IV and GyrA DNA Gyrase Subunits from Recent Fluoroquinolone-Resistant Streptococcus pneumoniae Clinical Isolates.

PMID: 15917550
Not Validated
-S83L--
ciprofloxacin
2006

Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.

PMID: 16451415
Not Validated
-S83F--
levofloxacin
2007

Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy.

PMID: 17517837
Not Validated
-Y83C--
ofloxacin
2008

Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.

PMID: 18083799
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-S83F--
ciprofloxacin
2005

Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.

PMID: 15963294
Not Validated
-S81Y--
fluoroquinolones
2003

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID: 16189113
Not Validated
-D87G--
ciprofloxacin
2007

Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.

PMID: 17043131
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-D87N--
ciprofloxacin|nalidixic acid
2005

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID: 16207965
Not Validated
-S83F--
ciprofloxacin
2006

Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003).

PMID: 16891509
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-E714K--
enrofloxacin
2008

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID: 18305127
Not Validated
-D87G--
ciprofloxacin|nalidixic acid
2005

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID: 16207965
Not Validated
-D87Y--
nalidixic acid
2006

Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.

PMID: 16416922
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-S83F--
ciprofloxacin
2007

International spread of multidrug-resistant Salmonella Schwarzengrund in food products.

PMID: 17553251
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-T678A--
enrofloxacin
2008

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID: 18305127
Not Validated
-D87N--
nalidixic acid
2006

Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.

PMID: 16416922
Not Validated
-T83I--
fluoroquinolones
2007

Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan.

PMID: 17122009
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87Y--
nalidixic acid|ciprofloxacin
2007

Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion.

PMID: 17596371
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-T83I--
fluoroquinolones
2006

Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.

PMID: 16451415
Not Validated
-S83L--
ciprofloxacin
2006

Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children.

PMID: 17005812
Not Validated
-S91T--
ciprofloxacin
2006

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID: 17207083
Not Validated
-D87N--
ciprofloxacin
2007

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID: 18217551
Not Validated
-T82I--
moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacin
2008

Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.

PMID: 18480338
Not Validated
-S83L--
ciprofloxacin
2008

Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

PMID: 18648533
Not Validated
-D87E--
nalidixic acid
2008

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID: 18708504
Not Validated
-S83L--
quinolones
2008

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID: 18708504
Not Validated
-S83A--
ciprofloxacin
1991

Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

PMID: 1850970
Not Validated
-Q106R--
ciprofloxacin
1991

Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

PMID: 1850970
Not Validated
-T82I-confers resistance
ciprofloxacin|moxifloxacin|levofloxacin
2009

Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model.

PMID: 18710908
Not Validated
-S83L--
ciprofloxacin
2008

Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California.

PMID: 18524965
Not Validated
-D87Y-confers resistance
ciprofloxacin
2009

Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.

PMID: 19104017
Not Validated
-T82I--
moxifloxacin|levofloxacin
2009

Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.

PMID: 19364867
Not Validated
-S83L--
fluoroquinolones
2009

A novel mechanism of transposon-mediated gene activation.

PMID: 19834539
Not Validated
-A147G--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S83L--
ciprofloxacin
2008

Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.

PMID: 18725452
Not Validated
-S81A--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S83L--
ciprofloxacin|levofloxacin
2008

Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.

PMID: 18591275
Not Validated
-S83I--
nalidixic acid|oxolinic acid|fluoroquinolones
2009

Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.

PMID: 19218407
Not Validated
-S81F--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S83L--
nalidixic acid
2008

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID: 18708504
Not Validated
-S83L--
fluoroquinolones
2010

Molecular Diagnostic Technologies in Clinical Microbiology

PMID: 19377839
Not Validated
-S81Y--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-D87N--
ciprofloxacin
2009

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID: 19205458
Not Validated
-S84L--
ciprofloxacin|levofloxacin
2010

Skin lesion caused by ST398 and ST1 MRSA, Spain.

PMID: 20031071
Not Validated
-S81F--
fluoroquinolones
2010

In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.

PMID: 20176911
Not Validated
-S84L--
fluoroquinolones
2010

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID: 20435780
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-E85K--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S83F--
ciprofloxacin
2009

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID: 19205458
Not Validated
-E85A--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S83Y--
ciprofloxacin
2010

Fluoroquinolone-resistant typhoid, South Africa.

PMID: 20409393
Not Validated
-D87G--
ciprofloxacin
2009

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID: 19205458
Not Validated
-T83I--
fluoroquinolones
2009

Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.

PMID: 19656662
Not Validated
-A90V--
fluoroquinolones
2009

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID: 19890396
Not Validated
-S82P--
moxifloxacin|levofloxacin|gemifloxacin
2010

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID: 20008781
Not Validated
-S81F--
fluoroquinolones
2010

In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.

PMID: 20176911
Not Validated
-S84L--
fluoroquinolones
2010

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID: 20435780
Not Validated
-N87I--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-S84L--
fluoroquinolones
2010

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID: 20435780
Not Validated
-D91N--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-D94G--
ofloxacin
2010

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID: 20573868
Not Validated
-R128S--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-S83F--
nalidixic acid|ciprofloxacin
2010

Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.

PMID: 20113512
Not Validated
-S84L--
fluoroquinolones
2010

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID: 20435780
Not Validated
-D91G--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-D94N--
ofloxacin
2010

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID: 20573868
Not Validated
-Y129C--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-S83F--
nalidixic acid|ciprofloxacin
2010

Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.

PMID: 20113512
Not Validated
-D91Y--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-A90V--
ofloxacin
2010

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID: 20573868
Not Validated
-S83L--
ciprofloxacin|ofloxacin
2010

Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi.

PMID: 20138477
Not Validated
-R140K--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-S83L--
levofloxacin
2010

The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.

PMID: 20597679
Not Validated
-G82D--
norfloxacin
2010

Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.

PMID: 20159551
Not Validated
-V150A--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-T82I--
moxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin
2010

Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018

PMID: 20554809
Not Validated
-D87E--
levofloxacin
2010

The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.

PMID: 20597679
Not Validated
-V150A--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-N87K--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-S83Y-reduced susceptibility to ciprofloxacin
ciprofloxacin
2010

In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.

PMID: 20566759
Not Validated
-S83L--
levofloxacin
2010

Impact of recA on levofloxacin exposure-related resistance development.

PMID: 20660686
Not Validated
-D94G--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-N87Y--
levofloxacin|moxifloxacin|ciprofloxacin
2010

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID: 20458765
Not Validated
-A90V--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-S83Y-reduced susceptibility to ciprofloxacin
ciprofloxacin
2010

In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.

PMID: 20566759
Not Validated
-S83L--
levofloxacin
2010

Impact of recA on levofloxacin exposure-related resistance development.

PMID: 20660686
Not Validated
-S95T--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-D94N--
fluoroquinolones
2010

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID: 20713679
Not Validated
-A70T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D85Y-Target modification
Nalidixic acid, Ciprofloxacin
2007

Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.

PMID: 18031331
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-S83R-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83N-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83I-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D85Y-Target modification
Nalidixic acid, Ciprofloxacin
2007

Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.

PMID: 18031331
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-S83I-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83Y-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-S83L-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-G81C-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-S83L-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-A70T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86A-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-S83N-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-S83Y-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83N-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83N-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-T86K-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-S83L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S97N-Target modification
Nalidixic acid, Ciprofloxacin
1999

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

PMID: 10508034
Not Validated
-S83R-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83L-Target modification
Nalidixic acid,Ciprofloxacin
1996

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID: 8891148
Not Validated
-S83V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-P104S-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-D90A-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-D90T-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-S83R-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-S83Y-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-G81D-Target modification
Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-D82G-Target modification
Nalidixic acid,Ciprofloxacin
1997

A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

PMID: 8980760
Not Validated
-S83W-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-S83V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-T86I-Target modification
Nalidixic acid, Ciprofloxacin
-Not Validated
-T86V-Target modification
Nalidixic acid, Ciprofloxacin
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
-D90N-Target modification
Nalidixic acid, Ciprofloxacin
1993

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID: 8384814
Not Validated
-P104S-Target modification
Nalidixic acid, Ciprofloxacin
2006

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID: 16713726
Not Validated
-S83R-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-S83I-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-G81C-Target modification
Nalidixic acid,Ciprofloxacin
1993

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID: 8392306
Not Validated
-S83L-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83I-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83Y-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-G81C-Target modification
Ciprofloxacin
1993

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID: 8392306
Not Validated
-S83W-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87Y-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87H-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S83L-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-S83A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87A-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-Q106R-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-S83L-Target modification
Nalidixic acid, Ciprofloxacin
1998

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID: 9527801
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-A67S-Target modification
Nalidixic acid
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-G81D-Target modification
Nalidixic acid,Ciprofloxacin
1993

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID: 8392306
Not Validated
-S83W-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-S83V-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-D87G-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-E87K-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-E87L-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-G81C-Target modification
Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-D82G-Target modification
Ciprofloxacin
1997

A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

PMID: 8980760
Not Validated
-S83V-Target modification
Nalidixic acid,Ciprofloxacin
1996

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID: 8891148
Not Validated
-D87N-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87A-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-A196E-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

PMID: 14506034
Not Validated
-E87G-Target modification
Nalidixic acid, Ciprofloxacin
2002

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID: 12373497
Not Validated
-S97N-Target modification
Nalidixic acid, Ciprofloxacin
1999

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

PMID: 10508034
Not Validated
-G81D-Target modification
Ciprofloxacin
1993

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID: 8392306
Not Validated
-S83A-Target modification
Nalidixic acid,Ciprofloxacin
1996

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID: 8891148
Not Validated
-A84P-Target modification
Nalidixic acid,Ciprofloxacin
2001

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID: 11451702
Not Validated
-D87N-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid
1991

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID: 1850972
Not Validated
-D87A-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-Q106H-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-A51V-Target modification
Nalidixic acid
2001

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID: 11451702
Not Validated
-G81D-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-S83W-Target modification
Nalidixic acid,Ciprofloxacin
1996

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID: 8891148
Not Validated
-A84V-Target modification
Nalidixic acid,Ciprofloxacin
1994

Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

PMID: 7840592
Not Validated
-D87Y-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87A-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87N-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87G-Target modification
Nalidixic acid,Ciprofloxacin
2012

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID: 22878251
Not Validated
-D87Y-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87H-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-D87V-Target modification
Nalidixic acid,Ciprofloxacin
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
-S83A-Target modification
Nalidixic acid,Ciprofloxacin
1990

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID: 2168148
Not Validated
-A84P-Target modification
Nalidixic acid,Ciprofloxacin
1994

Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

PMID: 7840592
Not Validated
-D87Y-Target modification
Nalidixic acid
2003

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID: 12654733
Not Validated
A258C---
fluoroquinolones
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
A259G---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
A259G---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
A259G---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
A259G---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
A261G---
ciprofloxacin
2004

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID: 14706091
Not Validated
A271T---
fluoroquinolones
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
AGT -> TTCS81F--
fluoroquinolones
2008

In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.

PMID: 17938189
Not Validated
AGT->GAA---
ciprofloxacin|nalidixic acid
2010

A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products.

PMID: 20363784
Not Validated
C257TS86L--
quinolone
2009

Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.

PMID: 19439549
Not Validated
C257TS86L--
quinolone
2009

Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.

PMID: 19439549
Not Validated
G210A---
fluoroquinolones
2001

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID: 11266291
Not Validated
G244C---
ciprofloxacin
2004

Dynamics of Long-Term Colonization of Respiratory Tract by Haemophilus influenzae in Cystic Fibrosis Patients Shows a Marked Increase in Hypermutable Strains.

PMID: 15070988
Not Validated
G247A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G247A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G247C---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G247C---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G248A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G248A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G248T---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G248T---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G249AS83L--
nalidixic acid|ciprofloxacin
2004

Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease.

PMID: 15387492
Not Validated
G249T---
fluoroquinolones
2008

Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States FoodNet multicenter retrospective cohort study.

PMID: 18212096
Not Validated
G259A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G259A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G260A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G260A---
fluoroquinolones
2010

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID: 20511368
Not Validated
G262TD88Y--
ciprofloxacin
2005

Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.

PMID: 15980348
Not Validated
G281AD94N--
fluoroquinolones
2007

In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.

PMID: 17938193
Not Validated
G81A---
ciprofloxacin
2001

Detection of Ciprofloxacin-Resistant Yersinia pestis by Fluorogenic PCR Using the LightCycler.

PMID: 11574586
Not Validated
GAT->AATD87N--
quinolones
2004

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID: 15364994
Not Validated
GAT->GGTD87G--
quinolones
2004

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID: 15364994
Not Validated
GAT->TATD87Y--
quinolones
2004

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID: 15364994
Not Validated
T1560A---
ciprofloxacin|levofloxacin|gatifloxacin
2008

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID: 18443108
Not Validated
T248A---
ciprofloxacin|norfloxacin
2009

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.

PMID: 18838592
Not Validated
T260A---
ciprofloxacin|norfloxacin
2009

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.

PMID: 18838592
Not Validated
T84CL84S--
ciprofloxacin
2007

Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.

PMID: 17986343
Not Validated
TCA->CTAS83L--
quinolones
2004

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID: 15364994
Not Validated
TCC->CTC---
ciprofloxacin
2004

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID: 14706091
Not Validated
Papers128
1

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID 22633335 · 2012

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
2

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.

PMID 10049284 · 1999

Mutation in gyrA at position 90 (A90V) confers resistance to fluoroquinolones.

Mutation Information

Gene Name
gyrA
Protein Change
A90V

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium bovis
3

Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.

PMID 10223929 · 1999

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

ciprofloxacin

Organisms Observed In

Vibrio parahaemolyticus
4

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID 10390214 · 1999

Mutation in gyrA codon 84 associated with ciprofloxacin resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus epidermidis
5

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID 10390214 · 1999

Mutation in gyrA codon 84 associated with ciprofloxacin resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus haemolyticus
6

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID 10390214 · 1999

Mutation in gyrA codon 84 associated with ciprofloxacin resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus hominis
7

Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.

PMID 10390214 · 1999

Mutation in gyrA codon 84 associated with ciprofloxacin resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus simulans
8

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
9

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter aerogenes
10

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
11

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter cloacae
12

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
13

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter cloacae
14

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter aerogenes
15

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella oxytoca
16

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter cloacae
17

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter aerogenes
18

Fluoroquinolone resistance in Bacteroides fragilis following sparfloxacin exposure.

PMID 10471574 · 1999

A mutation in the quinolone resistance-determining region (QRDR) of gyrA was identified as the mechanism of fluoroquinolone resistance in B. fragilis.

Mutation Information

Gene Name
gyrA
Protein Change
S89F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Bacteroides fragilis
19

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID 10991854 · 2000

Mutation Information

Gene Name
gyrA
Protein Change
S81Y

Confers Resistance To

clinafloxacin|ciprofloxacin|trovafloxacin

Organisms Observed In

Streptococcus pneumoniae
20

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
21

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
22

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
23

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
24

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
25

Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.

PMID 185097 · 1976

Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
Q106H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
26

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
27

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID 11451702 · 2001

Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
A84V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
28

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
29

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
30

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
31

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
32

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
33

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
34

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
35

Lysosomes as modulators of cellular functions. Influence on the synthesis and secretion of non-lysosomal materials.

PMID 185097 · 1976

Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
Q106R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
36

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
37

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
38

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
39

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
40

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
41

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
42

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
43

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
44

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
45

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
46

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
47

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
48

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
49

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
50

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
51

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
52

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
53

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
54

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID 22633335 · 2012

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
55

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID 22633335 · 2012

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
56

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID 22633335 · 2012

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
57

High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.

PMID 22633335 · 2012

Under development. Phenotype should be used with caution.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
58

Fluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophages.

PMID 10049284 · 1999

Mutation in gyrA at position 90 (A90V) confers resistance to fluoroquinolones.

Mutation Information

Gene Name
gyrA
Protein Change
A90V

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
59

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

PMID 12121955 · 2002

Mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
Y100D

Confers Resistance To

norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin

Organisms Observed In

Vibrio cholerae
60

Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America.

PMID 12791865 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

levofloxacin

Organisms Observed In

Streptococcus pneumoniae
61

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
62

Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.

PMID 10602715 · 2000

Mutation in gyrA contributes to fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ofloxacin|ciprofloxacin|trovafloxacin|sparfloxacin

Organisms Observed In

Escherichia coli
63

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID 10991854 · 2000

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

clinafloxacin|ciprofloxacin|trovafloxacin

Organisms Observed In

Streptococcus pneumoniae
64

Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.

PMID 11709337 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

quinolones

Organisms Observed In

Staphylococcus aureus
65

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterobacter aerogenes
66

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID 10991854 · 2000

Mutation Information

Gene Name
gyrA
Protein Change
S81L

Confers Resistance To

clinafloxacin|ciprofloxacin|trovafloxacin

Organisms Observed In

Streptococcus pneumoniae
67

Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.

PMID 10428935 · 1999

mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Confers Resistance To

ciprofloxacin

Organisms Observed In

Klebsiella pneumoniae
68

In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.

PMID 10991854 · 2000

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

clinafloxacin|ciprofloxacin|trovafloxacin

Organisms Observed In

Streptococcus pneumoniae
69

Antimicrobial resistance and bacterial identification utilizing a microelectronic chip array.

PMID 11230433 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Confers Resistance To

fluoroquinolones

Organisms Observed In

Campylobacter jejuni
70

Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.

PMID 11751133 · 2002

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Staphylococcus aureus
71

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

PMID 14506034 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

mutations in gyrA confer resistance to fluoroquinolones

Confers Resistance To

norfloxacin|ciprofloxacin

Organisms Observed In

Escherichia coli
72

An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones.

PMID 10799008 · 2000

Mutation in the quinolone resistance determining region (QRDR) of the gyrA gene

Mutation Information

Gene Name
gyrA
Protein Change
D95N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria meningitidis
73

Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae.

PMID 11036007 · 2000

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

levofloxacin|clinafloxacin

Organisms Observed In

Streptococcus pneumoniae
74

Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.

PMID 11451695 · 2001

Thirteen isolates showed the same nucleotide transition (ACT→ATT) resulting in a threonine→isoleucine change. In one isolate (1542), two nucleotide changes (ACT→GTT) resulted in a replacement of threonine by valine.

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

moxifloxacin

Organisms Observed In

Clostridium difficile
75

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

PMID 12121955 · 2002

Mutations in gyrA are associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

norfloxacin|ciprofloxacin|sparfloxacin|ofloxacin

Organisms Observed In

Vibrio cholerae
76

Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.

PMID 11257024 · 2001

Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Effect on Function

reduced potency of ciprofloxacin

Confers Resistance To

quinolones

Organisms Observed In

Staphylococcus aureus
77

gyrA Mutations Associated with Quinolone Resistance in Bacteroides fragilis Group Strains.

PMID 11408211 · 2001

Mutations at position 82 (Ser82Leu) were associated with high-level resistance to all quinolones tested.

Mutation Information

Gene Name
gyrA
Protein Change
S82L

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin|clinafloxacin

Organisms Observed In

Bacteroides fragilis
78

Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.

PMID 11600359 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
S85P

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus aureus
79

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID 12878509 · 2003

Mutations in gyrA contribute to levofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
E85K

Confers Resistance To

levofloxacin

Organisms Observed In

Streptococcus pneumoniae
80

Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures.

PMID 11600360 · 2001

Single point mutations in gyrA are associated with reduced susceptibility to fluoroquinolones.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin|ofloxacin|nalidixic acid

Organisms Observed In

Escherichia coli
81

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID 12384345 · 2002

Mutation Information

Gene Name
gyrA
Protein Change
D71V

Confers Resistance To

Ciprofloxacin|Moxifloxacin

Organisms Observed In

Clostridium difficile
82

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID 12878509 · 2003

Mutations in gyrA contribute to levofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
E85K

Confers Resistance To

levofloxacin

Organisms Observed In

Streptococcus pneumoniae
83

Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.

PMID 15917569 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

ciprofloxacin|garenoxacin

Organisms Observed In

Pseudomonas aeruginosa
84

Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.

PMID 11796356 · 2002

Mutation Information

Gene Name
gyrA
Protein Change
S95T

Confers Resistance To

ofloxacin

Organisms Observed In

Mycobacterium tuberculosis
85

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID 12384345 · 2002

Mutation Information

Gene Name
gyrA
Protein Change
T82I

Confers Resistance To

Ciprofloxacin|Moxifloxacin

Organisms Observed In

Clostridium difficile
86

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID 12878509 · 2003

Mutations in gyrA contribute to levofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
P162T

Confers Resistance To

levofloxacin

Organisms Observed In

Streptococcus pneumoniae
87

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.

PMID 11699598 · 2001

Mutations in gyrA alone or in combination with parC were linked to nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

nalidixic acid

Organisms Observed In

Escherichia coli
88

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID 12384345 · 2002

Mutation Information

Gene Name
gyrA
Protein Change
A118T

Confers Resistance To

Ciprofloxacin|Moxifloxacin

Organisms Observed In

Clostridium difficile
89

A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.

PMID 12450802 · 2002

Mutation in the quinolone resistance-determining region

Mutation Information

Gene Name
gyrA
Protein Change
L83F

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Escherichia coli
90

Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro.

PMID 12878509 · 2003

Mutations in gyrA contribute to levofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
P162T

Confers Resistance To

levofloxacin

Organisms Observed In

Streptococcus pneumoniae
91

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.

PMID 11699598 · 2001

Mutations in gyrA alone or in combination with parC were linked to nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
D107E

Confers Resistance To

nalidixic acid

Organisms Observed In

Escherichia coli
92

A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.

PMID 12450802 · 2002

Mutation in the quinolone resistance-determining region

Mutation Information

Gene Name
gyrA
Protein Change
L83F

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Salmonella typhimurium
93

Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.

PMID 14718091 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
94

Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003.

PMID 15498176 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
95

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S87V

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Corynebacterium striatum
96

Ciprofloxacin susceptibility of Pseudomonas aeruginosa isolates from keratitis.

PMID 14507757 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

ciprofloxacin

Organisms Observed In

Pseudomonas aeruginosa
97

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
98

Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.

PMID 15380025 · 2004

Five isolates had this mutation.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
99

Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.

PMID 15673754 · 2005

The Thr-86→Ile mutation in gyrA was the most common mutation associated with ciprofloxacin and nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Campylobacter coli
100

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
101

Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.

PMID 15380025 · 2004

Five isolates had this mutation.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
102

Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment.

PMID 15673754 · 2005

The Thr-86→Ile mutation in gyrA was the most common mutation associated with ciprofloxacin and nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Campylobacter jejuni
103

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
104

Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.

PMID 15243093 · 2004

associated with ciprofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
S91F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Neisseria gonorrhoeae
105

Isolation and molecular characterization of fluoroquinolone-resistant Escherichia coli from poultry litter.

PMID 15685943 · 2005

Single mutation at Ser83Leu or Asp87Asn associated with low-level resistance; double mutations at Ser83Leu and Asp87Asn associated with high-level resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
106

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D91Y

Confers Resistance To

ciprofloxacin|levofloxacin

Organisms Observed In

Corynebacterium striatum
107

Ciprofloxacin treatment failure in typhoid fever case, Pakistan.

PMID 14720407 · 2003

Single point mutation in the quinolone-resistance-determining region (QRDR) of the topoisomerase gene gyrA

Mutation Information

Gene Name
gyrA
Protein Change
D83N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
108

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
109

Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.

PMID 15388428 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
110

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S87R

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Corynebacterium amycolatum
111

Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

PMID 14982762 · 2004

Mutation in gyrA leads to quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S81Y

Confers Resistance To

ciprofloxacin|garenoxacin|sparfloxacin|trovafloxacin

Organisms Observed In

Streptococcus pneumoniae
112

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
113

An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.

PMID 15567276 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

ciprofloxacin|norfloxacin

Organisms Observed In

Aeromonas caviae
114

Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

PMID 15728901 · 2005

Mutations in gyrA were associated with increased resistance to fluoroquinolones.

Mutation Information

Gene Name
gyrA
Protein Change
S81Y

Confers Resistance To

gemifloxacin|trovafloxacin|sparfloxacin|ciprofloxacin

Organisms Observed In

Streptococcus pneumoniae
115

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S87R

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Corynebacterium striatum
116

Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.

PMID 15917531 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
A119E

Confers Resistance To

norfloxacin

Organisms Observed In

Escherichia coli
117

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID 14706091 · 2004

Most frequent mutation

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Escherichia coli
118

Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.

PMID 15078598 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
119

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
A88P

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Corynebacterium amycolatum
120

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S87F

Confers Resistance To

ciprofloxacin|levofloxacin

Organisms Observed In

Corynebacterium striatum
121

Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates.

PMID 15388458 · 2004

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Streptococcus pneumoniae
122

Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.

PMID 15855486 · 2005

mutations in the QRDR of the gyrA gene are associated with quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
A88P

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin

Organisms Observed In

Corynebacterium striatum
123

Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones.

PMID 16145072 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
S91F

Confers Resistance To

ciprofloxacin|gatifloxacin|levofloxacin|ofloxacin

Organisms Observed In

Neisseria gonorrhoeae
124

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID 16189113 · 2003

Mutations in gyrA are associated with fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
125

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria meningitidis
126

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
127

Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.

PMID 18411315 · 2008

Mutation in gyrA leads to fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

likely ascribed to the previously characterized mutation occurring in the gyrA gene, with a substitution of Ser for Leu at position 83 of its amino acid sequence

Confers Resistance To

fluoroquinolones

Organisms Observed In

Acinetobacter baumannii
128

Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.

PMID 15963294 · 2005

Mutations in gyrA and parC contribute to ciprofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
129

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID 16189113 · 2003

Mutations in gyrA are associated with fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
E85K

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
130

High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.

PMID 16517894 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
S83R

Confers Resistance To

ciprofloxacin

Organisms Observed In

Enterococcus faecium
131

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria subflava
132

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
133

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

enrofloxacin

Organisms Observed In

Staphylococcus pseudintermedius
134

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID 18443108 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin|levofloxacin|gatifloxacin

Organisms Observed In

Staphylococcus aureus
135

Fluoroquinolone-resistant Salmonella sp. in carcasses.

PMID 17080579 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Salmonella enterica
136

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria flavescens
137

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
E88G

Confers Resistance To

enrofloxacin

Organisms Observed In

Staphylococcus pseudintermedius
138

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID 16207965 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Salmonella enterica
139

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria cinerea
140

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
141

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
Q611L

Confers Resistance To

enrofloxacin

Organisms Observed In

Staphylococcus pseudintermedius
142

Novel Ser79Leu and Ser81Ile Substitutions in the Quinolone Resistance-Determining Regions of ParC Topoisomerase IV and GyrA DNA Gyrase Subunits from Recent Fluoroquinolone-Resistant Streptococcus pneumoniae Clinical Isolates.

PMID 15917550 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
S81I

Confers Resistance To

ciprofloxacin|levofloxacin|moxifloxacin|gatifloxacin|gemifloxacin|garenoxacin|norfloxacin

Organisms Observed In

Streptococcus pneumoniae
143

Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.

PMID 16451415 · 2006

mutations in the quinolone resistance-determining regions of gyrA and parC

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Pseudomonas aeruginosa
144

Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy.

PMID 17517837 · 2007

Mutations in gyrA were associated with reduced susceptibility to levofloxacin.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

levofloxacin

Organisms Observed In

Yersinia pestis
145

Interstrain gene transfer in Chlamydia trachomatis in vitro: mechanism and significance.

PMID 18083799 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
Y83C

Confers Resistance To

ofloxacin

Organisms Observed In

Chlamydia trachomatis
146

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
147

Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.

PMID 15963294 · 2005

Mutations in gyrA and parC contribute to ciprofloxacin resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
148

Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae

PMID 16189113 · 2003

Mutations in gyrA are associated with fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S81Y

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
149

Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.

PMID 17043131 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
150

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria lactamica
151

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
152

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID 16207965 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Salmonella enterica
153

Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003).

PMID 16891509 · 2006

Single mutation in gyrA gene associated with reduced ciprofloxacin susceptibility.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
154

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria elongata
155

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
156

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
E714K

Confers Resistance To

enrofloxacin

Organisms Observed In

Staphylococcus pseudintermedius
157

Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.

PMID 16207965 · 2005

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Salmonella enterica
158

Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.

PMID 16416922 · 2006

Mutations in the quinolone resistance-determining region of gyrA contribute to nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Confers Resistance To

nalidixic acid

Organisms Observed In

Salmonella enterica
159

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria mucosa
160

International spread of multidrug-resistant Salmonella Schwarzengrund in food products.

PMID 17553251 · 2007

Single base substitution in gyrA gene at codon 83 (Ser→Phe) and 87 (Asp→Asn)

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
161

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
162

Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.

PMID 18305127 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
T678A

Confers Resistance To

enrofloxacin

Organisms Observed In

Staphylococcus pseudintermedius
163

Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.

PMID 16416922 · 2006

Mutations in the quinolone resistance-determining region of gyrA contribute to nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

nalidixic acid

Organisms Observed In

Salmonella enterica
164

Outbreaks of multidrug-resistant Pseudomonas aeruginosa in community hospitals in Japan.

PMID 17122009 · 2007

associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

fluoroquinolones

Organisms Observed In

Pseudomonas aeruginosa
165

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria sicca
166

Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion.

PMID 17596371 · 2007

The Asp87Tyr substitution was observed in all resistant isolates.

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Salmonella enterica
167

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
168

Genetic analysis of a multiresistant strain of Pseudomonas aeruginosa producing PER-1 beta-lactamase.

PMID 16451415 · 2006

mutations in the quinolone resistance-determining regions of gyrA and parC

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

fluoroquinolones

Organisms Observed In

Pseudomonas aeruginosa
169

Ciprofloxacin-resistant gram-negative bacilli in the fecal microflora of children.

PMID 17005812 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
170

Pyrosequencing of the DNA gyrase gene in Neisseria species: effective indicator of ciprofloxacin resistance in Neisseria gonorrhoeae.

PMID 17207083 · 2006

Wild-type gyrA sequence is susceptible to ciprofloxacin

Mutation Information

Gene Name
gyrA
Protein Change
S91T

Confers Resistance To

ciprofloxacin

Organisms Observed In

Neisseria gonorrhoeae
171

Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.

PMID 18217551 · 2007

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
172

Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.

PMID 18480338 · 2008

Thr82Ile was the most frequent amino acid change identified

Mutation Information

Gene Name
gyrA
Protein Change
T82I

Confers Resistance To

moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacin

Organisms Observed In

Clostridium difficile
173

Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

PMID 18648533 · 2008

Mutations in gyrA and parC were associated with fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
174

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID 18708504 · 2008

Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
D87E

Confers Resistance To

nalidixic acid

Organisms Observed In

Escherichia coli
175

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID 18708504 · 2008

Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

quinolones

Organisms Observed In

Escherichia coli
176

Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

PMID 1850970 · 1991

Mutant enzymes required 10 times more drug to inhibit reaction

Mutation Information

Gene Name
gyrA
Protein Change
S83A

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
177

Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins.

PMID 1850970 · 1991

Mutant enzymes required 10 times more drug to inhibit reaction

Mutation Information

Gene Name
gyrA
Protein Change
Q106R

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
178

Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model.

PMID 18710908 · 2009

Mutation present in both parent strains and resistant mutants.

Mutation Information

Gene Name
gyrA
Protein Change
T82I

Effect on Function

confers resistance

Confers Resistance To

ciprofloxacin|moxifloxacin|levofloxacin

Organisms Observed In

Clostridium difficile
179

Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California.

PMID 18524965 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Acinetobacter baumannii
180

Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.

PMID 19104017 · 2009

Single mutation in all high-level nalidixic acid-resistant strains.

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

confers resistance

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
181

Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.

PMID 19364867 · 2009

Mutation Information

Gene Name
gyrA
Protein Change
T82I

Confers Resistance To

moxifloxacin|levofloxacin

Organisms Observed In

Clostridium difficile
182

A novel mechanism of transposon-mediated gene activation.

PMID 19834539 · 2009

Mutation in gyrA was shown to contribute to fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

fluoroquinolones
183

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
A147G

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
184

Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.

PMID 18725452 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin

Organisms Observed In

Acinetobacter baumannii
185

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
S81A

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
186

Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.

PMID 18591275 · 2008

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin|levofloxacin

Organisms Observed In

Acinetobacter baumannii
187

Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.

PMID 19218407 · 2009

Mutation in gyrA leads to quinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Confers Resistance To

nalidixic acid|oxolinic acid|fluoroquinolones

Organisms Observed In

Vibrio vulnificus
188

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
189

Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5

PMID 18708504 · 2008

Single amino acid substitutions in GyrA are sufficient for high-level nalidixic acid resistance.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

nalidixic acid

Organisms Observed In

Escherichia coli
190

Molecular Diagnostic Technologies in Clinical Microbiology

PMID 19377839 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Pseudomonas aeruginosa
191

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
S81Y

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
192

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID 19205458 · 2009

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella
193

Skin lesion caused by ST398 and ST1 MRSA, Spain.

PMID 20031071 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

ciprofloxacin|levofloxacin

Organisms Observed In

Staphylococcus aureus
194

In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.

PMID 20176911 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Staphylococcus aureus
195

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID 20435780 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Staphylococcus epidermidis

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
197

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
E85K

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
198

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID 19205458 · 2009

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella
199

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
E85A

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
200

Fluoroquinolone-resistant typhoid, South Africa.

PMID 20409393 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
201

Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.

PMID 19205458 · 2009

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella
202

Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa.

PMID 19656662 · 2009

Mutations in codons 83 and 87 of gyrA are associated with fluoroquinolone resistance.

Mutation Information

Gene Name
gyrA
Protein Change
T83I

Confers Resistance To

fluoroquinolones

Organisms Observed In

Pseudomonas aeruginosa
203

Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

PMID 19890396 · 2009

Mutation Information

Gene Name
gyrA
Protein Change
A90V

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
204

Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.

PMID 20008781 · 2010

mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
S82P

Confers Resistance To

moxifloxacin|levofloxacin|gemifloxacin

Organisms Observed In

Streptococcus pneumoniae
205

In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.

PMID 20176911 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S81F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
206

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID 20435780 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Staphylococcus aureus
207

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
N87I

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
208

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID 20435780 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
209

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D91N

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
210

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID 20573868 · 2010

detected by MTBDRsl assay

Mutation Information

Gene Name
gyrA
Protein Change
D94G

Confers Resistance To

ofloxacin

Organisms Observed In

Mycobacterium tuberculosis
211

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
R128S

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
212

Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.

PMID 20113512 · 2010

Multiple substitutions observed, including Ser83→Phe, Ser83→Pro, Ser83→Tyr, Asp87→Gly, and Asp87→Asn.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Salmonella enterica
213

Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.

PMID 20435780 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S84L

Confers Resistance To

fluoroquinolones

Organisms Observed In

Haemophilus influenzae
214

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D91G

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
215

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID 20573868 · 2010

detected by MTBDRsl assay

Mutation Information

Gene Name
gyrA
Protein Change
D94N

Confers Resistance To

ofloxacin

Organisms Observed In

Mycobacterium tuberculosis
216

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
Y129C

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
217

Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.

PMID 20113512 · 2010

Multiple substitutions observed, including Ser83→Phe, Ser83→Pro, Ser83→Tyr, Asp87→Gly, and Asp87→Asn.

Mutation Information

Gene Name
gyrA
Protein Change
S83F

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

Salmonella enterica
218

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
D91Y

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
219

Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.

PMID 20573868 · 2010

detected by MTBDRsl assay

Mutation Information

Gene Name
gyrA
Protein Change
A90V

Confers Resistance To

ofloxacin

Organisms Observed In

Mycobacterium tuberculosis
220

Intrinsic fluoroquinolone resistance in Orientia tsutsugamushi.

PMID 20138477 · 2010

All 18 isolates from Laos and the two genome sequences (Boryong and Ikeda) showed the same mutation.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

ciprofloxacin|ofloxacin

Organisms Observed In

Orientia tsutsugamushi
221

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
R140K

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
222

The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.

PMID 20597679 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

levofloxacin

Organisms Observed In

Escherichia coli
223

Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.

PMID 20159551 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
G82D

Confers Resistance To

norfloxacin

Organisms Observed In

E. coli
224

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
V150A

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
225

Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018

PMID 20554809 · 2010

Mutation in gyrA confers resistance to fluoroquinolones

Mutation Information

Gene Name
gyrA
Protein Change
T82I

Confers Resistance To

moxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin

Organisms Observed In

Clostridium difficile
226

The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients.

PMID 20597679 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
D87E

Confers Resistance To

levofloxacin

Organisms Observed In

Escherichia coli
227

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
V150A

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
228

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
N87K

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
229

In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.

PMID 20566759 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

reduced susceptibility to ciprofloxacin

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
230

Impact of recA on levofloxacin exposure-related resistance development.

PMID 20660686 · 2010

Additional mutations in gyrA (e.g., S84A, S84L, S84P, E88G, and E88K) were found in all the levofloxacin-resistant isolates.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

levofloxacin

Organisms Observed In

Escherichia coli
231

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
D94G

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
232

Distribution of gyrA mutations in fluoroquinolone-resistant Helicobacter pylori strains.

PMID 20458765 · 2010

Mutations in the gyrA gene were associated with fluoroquinolone resistance

Mutation Information

Gene Name
gyrA
Protein Change
N87Y

Confers Resistance To

levofloxacin|moxifloxacin|ciprofloxacin

Organisms Observed In

Helicobacter pylori
233

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
A90V

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
234

In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.

PMID 20566759 · 2010

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

reduced susceptibility to ciprofloxacin

Confers Resistance To

ciprofloxacin

Organisms Observed In

Salmonella enterica
235

Impact of recA on levofloxacin exposure-related resistance development.

PMID 20660686 · 2010

Additional mutations in gyrA (e.g., S84A, S84L, S84P, E88G, and E88K) were found in all the levofloxacin-resistant isolates.

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Confers Resistance To

levofloxacin

Organisms Observed In

Staphylococcus aureus
236

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
S95T

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
237

Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.

PMID 20713679 · 2010

Previously reported

Mutation Information

Gene Name
gyrA
Protein Change
D94N

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
238

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
A70T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
239

Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.

PMID 18031331 · 2007

Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D85Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
240

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
242

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
243

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
244

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
246

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
247

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
248

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
249

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
251

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
252

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
253

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
254

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
255

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
256

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
257

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
258

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
259

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
260

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
261

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
262

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
263

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
264

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
265

Antibiotic resistance and resistance mechanisms in Campylobacter jejuni and Campylobacter coli.

PMID 18031331 · 2007

Phenotype described only in association with other mutations (T86), unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D85Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
267

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
270

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
271

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
272

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
273

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
274

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
275

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
276

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
277

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
278

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
279

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
280

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
281

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81C

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
282

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
283

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
284

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
285

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
286

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
287

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
A70T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
288

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
289

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
290

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
291

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
292

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
293

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
294

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
295

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
296

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
297

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
298

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
299

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
300

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
301

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
302

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
303

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

PMID 10508034 · 1999

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S97N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
304

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
305

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
306

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID 8891148 · 1996

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
307

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
308

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
309

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
P104S

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter jejuni
310

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
311

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Mutation Information

Gene Name
gyrA
Protein Change
D90A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
312

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90T

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
313

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
314

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
315

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
316

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81D

Effect on Function

Target modification

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Escherichia coli
317

A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

PMID 8980760 · 1997

D82G mutation confers resistance to ciprofloxacin only. If D82G and G81D are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
D82G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
318

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83W

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
319

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli

Mutation Information

Gene Name
gyrA
Protein Change
T86I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
321

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
T86V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
322

Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.

PMID 8384814 · 1993

Mutation Information

Gene Name
gyrA
Protein Change
D90N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
323

Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.

PMID 16713726 · 2006

Phenotype described only in association with other mutations (R285), unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
P104S

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Campylobacter coli
324

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
325

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
326

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
327

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
328

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
329

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID 8392306 · 1993

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81C

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
330

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
331

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
332

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
333

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83I

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
334

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
335

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID 8392306 · 1993

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81C

Effect on Function

Target modification

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Escherichia coli
336

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83W

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
337

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
338

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
339

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
340

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
341

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecalis
342

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
343

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
344

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

Mutation Information

Gene Name
gyrA
Protein Change
S83A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
345

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
346

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
347

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
348

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
349

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
350

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
351

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
352

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
Q106R

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
353

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S83L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
354

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
355

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
356

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Mutation Information

Gene Name
gyrA
Protein Change
A67S

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
357

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID 8392306 · 1993

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81D

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
358

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Mutation Information

Gene Name
gyrA
Protein Change
S83W

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
359

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Mutation Information

Gene Name
gyrA
Protein Change
S83V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
360

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
361

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
362

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
363

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
364

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
365

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
366

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87K

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
367

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87L

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
368

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81C

Effect on Function

Target modification

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Escherichia coli
369

A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

PMID 8980760 · 1997

D82G mutation confers resistance to ciprofloxacin only. If D82G and G81D are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
D82G

Effect on Function

Target modification

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Escherichia coli
370

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID 8891148 · 1996

Mutation Information

Gene Name
gyrA
Protein Change
S83V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
371

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
372

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
373

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
374

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
375

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
376

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
377

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
378

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
379

Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.

PMID 14506034 · 2003

Unknown phenotype if A196E occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
A196E

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
380

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
E87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
381

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.

PMID 10508034 · 1999

Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
S97N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid, Ciprofloxacin

Organisms Observed In

Enterococcus faecium
382

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid.

PMID 8392306 · 1993

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81D

Effect on Function

Target modification

Confers Resistance To

Ciprofloxacin

Organisms Observed In

Escherichia coli
383

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID 8891148 · 1996

Mutation Information

Gene Name
gyrA
Protein Change
S83A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
384

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID 11451702 · 2001

Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
A84P

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
385

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
386

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.

PMID 1850972 · 1991

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
387

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
388

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
389

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
390

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
391

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
392

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Unknown phenotype if Q106H occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
Q106H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
393

Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.

PMID 11451702 · 2001

Mutation Information

Gene Name
gyrA
Protein Change
A51V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
394

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

G81D mutation confers resistance to ciprofloxacin only. If G81D and D82G are present simultaneously, there is also nalidixic acid resistance

Mutation Information

Gene Name
gyrA
Protein Change
G81D

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
395

Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.

PMID 8891148 · 1996

Mutation Information

Gene Name
gyrA
Protein Change
S83W

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
396

Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

PMID 7840592 · 1994

Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
A84V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
397

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
398

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
399

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
400

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87N

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
401

Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

PMID 22878251 · 2012

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87G

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
402

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
403

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87H

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
404

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87V

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
405

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

PMID 2168148 · 1990

Mutation Information

Gene Name
gyrA
Protein Change
S83A

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
406

Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.

PMID 7840592 · 1994

Unknown phenotype if A84P or A84V occur alone. Nalidixic acid and ciprofloxacin resistance when associated with other gyrA mutations

Mutation Information

Gene Name
gyrA
Protein Change
A84P

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid,Ciprofloxacin

Organisms Observed In

Escherichia coli
407

Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.

PMID 12654733 · 2003

D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone

Mutation Information

Gene Name
gyrA
Protein Change
D87Y

Effect on Function

Target modification

Confers Resistance To

Nalidixic acid

Organisms Observed In

Escherichia coli
408

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Nucleotide Change
A258C

Confers Resistance To

fluoroquinolones

Organisms Observed In

Campylobacter jejuni
409

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
A259G

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
410

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
A259G

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
411

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
A259G

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
412

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
A259G

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
413

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID 14706091 · 2004

Most frequent mutation

Mutation Information

Gene Name
gyrA
Nucleotide Change
A261G

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli
414

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Nucleotide Change
A271T

Confers Resistance To

fluoroquinolones

Organisms Observed In

Campylobacter jejuni
415

In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.

PMID 17938189 · 2008

Mutation detected in quinolone-resistant strains

Mutation Information

Gene Name
gyrA
Nucleotide Change
AGT -> TTC
Protein Change
S81F

Confers Resistance To

fluoroquinolones

Organisms Observed In

Streptococcus pneumoniae
416

A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products.

PMID 20363784 · 2010

Mutation in the quinolone resistance-determining region

Mutation Information

Gene Name
gyrA
Nucleotide Change
AGT->GAA

Confers Resistance To

ciprofloxacin|nalidixic acid

Organisms Observed In

Salmonella enterica
417

Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.

PMID 19439549 · 2009

mutation in gyrA confers quinolone resistance

Mutation Information

Gene Name
gyrA
Nucleotide Change
C257T
Protein Change
S86L

Confers Resistance To

quinolone

Organisms Observed In

Campylobacter jejuni
418

Multiplex strategy for multilocus sequence typing, fla typing, and genetic determination of antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates collected in Switzerland.

PMID 19439549 · 2009

mutation in gyrA confers quinolone resistance

Mutation Information

Gene Name
gyrA
Nucleotide Change
C257T
Protein Change
S86L

Confers Resistance To

quinolone

Organisms Observed In

Campylobacter coli
419

Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.

PMID 11266291 · 2001

Mutation Information

Gene Name
gyrA
Nucleotide Change
G210A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Campylobacter jejuni
420

Dynamics of Long-Term Colonization of Respiratory Tract by Haemophilus influenzae in Cystic Fibrosis Patients Shows a Marked Increase in Hypermutable Strains.

PMID 15070988 · 2004

Mutations in gyrA were associated with ciprofloxacin resistance.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G244C

Confers Resistance To

ciprofloxacin

Organisms Observed In

Haemophilus influenzae
421

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G247A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
422

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G247A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
423

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G247C

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
424

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G247C

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
425

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G248A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
426

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G248A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
427

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G248T

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
428

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G248T

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
429

Emerging nalidixic acid and ciprofloxacin resistance in non-typhoidal Salmonella isolated from patients having acute diarrhoeal disease.

PMID 15387492 · 2004

Mutations in gyrA were associated with quinolone resistance.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G249A
Protein Change
S83L

Confers Resistance To

nalidixic acid|ciprofloxacin

Organisms Observed In

non-typhoidal Salmonella
430

Clinical response and outcome of infection with Salmonella enterica serotype Typhi with decreased susceptibility to fluoroquinolones: a United States FoodNet multicenter retrospective cohort study.

PMID 18212096 · 2008

Mutations in gyrA were associated with decreased susceptibility to fluoroquinolones.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G249T

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
431

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G259A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
432

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G259A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
433

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G260A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
434

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

Gene Name
gyrA
Nucleotide Change
G260A

Confers Resistance To

fluoroquinolones

Organisms Observed In

Salmonella enterica
435

Novel approach to mapping of resistance mutations in whole genomes by using restriction enzyme modulation of transformation efficiency.

PMID 15980348 · 2005

Mutation Information

Gene Name
gyrA
Nucleotide Change
G262T
Protein Change
D88Y

Confers Resistance To

ciprofloxacin

Organisms Observed In

Haemophilus influenzae
436

In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.

PMID 17938193 · 2007

Detected in mice treated with 0.25% MXF

Mutation Information

Gene Name
gyrA
Nucleotide Change
G281A
Protein Change
D94N

Confers Resistance To

fluoroquinolones

Organisms Observed In

Mycobacterium tuberculosis
437

Detection of Ciprofloxacin-Resistant Yersinia pestis by Fluorogenic PCR Using the LightCycler.

PMID 11574586 · 2001

Mutant M1

Mutation Information

Gene Name
gyrA
Nucleotide Change
G81A

Confers Resistance To

ciprofloxacin

Organisms Observed In

Yersinia pestis
438

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID 15364994 · 2004

Single nucleotide exchange at position 83

Mutation Information

Gene Name
gyrA
Nucleotide Change
GAT->AAT
Protein Change
D87N

Confers Resistance To

quinolones

Organisms Observed In

Escherichia coli
439

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID 15364994 · 2004

Single nucleotide exchange at position 83

Mutation Information

Gene Name
gyrA
Nucleotide Change
GAT->GGT
Protein Change
D87G

Confers Resistance To

quinolones

Organisms Observed In

Escherichia coli
440

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID 15364994 · 2004

Single nucleotide exchange at position 83

Mutation Information

Gene Name
gyrA
Nucleotide Change
GAT->TAT
Protein Change
D87Y

Confers Resistance To

quinolones

Organisms Observed In

Escherichia coli
441

In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

PMID 18443108 · 2008

Mutation Information

Gene Name
gyrA
Nucleotide Change
T1560A

Confers Resistance To

ciprofloxacin|levofloxacin|gatifloxacin

Organisms Observed In

Staphylococcus aureus
442

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.

PMID 18838592 · 2009

Mutation Information

Gene Name
gyrA
Nucleotide Change
T248A

Confers Resistance To

ciprofloxacin|norfloxacin

Organisms Observed In

Escherichia coli
443

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.

PMID 18838592 · 2009

Mutation Information

Gene Name
gyrA
Nucleotide Change
T260A

Confers Resistance To

ciprofloxacin|norfloxacin

Organisms Observed In

Escherichia coli
444

Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus.

PMID 17986343 · 2007

The serine-containing GyrA protein confers resistance to ciprofloxacin.

Mutation Information

Gene Name
gyrA
Nucleotide Change
T84C
Protein Change
L84S

Confers Resistance To

ciprofloxacin

Organisms Observed In

Staphylococcus aureus
445

Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.

PMID 15364994 · 2004

Single nucleotide exchange at position 83

Mutation Information

Gene Name
gyrA
Nucleotide Change
TCA->CTA
Protein Change
S83L

Confers Resistance To

quinolones

Organisms Observed In

Escherichia coli
446

Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.

PMID 14706091 · 2004

Most frequent mutation

Mutation Information

Gene Name
gyrA
Nucleotide Change
TCC->CTC

Confers Resistance To

ciprofloxacin

Organisms Observed In

Escherichia coli