Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| - |
| single resistance variant |
| Mycobacterium tuberculosis |
Rifampicin |
Card Database |
| Established |
| D435V | substitutes the negatively charged aspartate with a bulkier nonpolar valine residue causing steric hindrance within the rifampicin-binding pocket, increased IC 50 of both rifamycins, single resistance variant, multiple resistance variants | Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis, Escherichia coli | RifampicinCapreomycinCAP+3 more | Card DatabaseResFinder DatabaseReslit | Confirmed |
| D435Var | - | single resistance variant | Mycobacterium tuberculosis | Rifampicin | Card Database | Established |
| D435X | - | - | Mycobacterium tuberculosis | Rifampicin | Reslit | Candidate |
| D435Y | single resistance variant, multiple resistance variants | Mycobacterium tuberculosis | RifampicinRifampin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| D441A | - | loss of interactions with drug except Gly438, Phe439 and Arg465 | Mycobacterium tuberculosis | Rifampicin | Reslit | Candidate |
| D441C | - | - | Mycobacterium tuberculosis | Rifampicin | Reslit | Candidate |
| D441F | - | - | Mycobacterium tuberculosis | Rifampicin | Reslit | Candidate |
| D441N | - | - | Mycobacterium tuberculosis, Mycobacterium leprae | Rifampicin | Reslit | Candidate |
© 2026 ResLit. Data sourced from PubMed literature analysis.
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