Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	I491F	A1473T A1472T	confers rifampicin resistance, single resistance variant	Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium kansasii, Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium smegmatis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	I491L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	I491M	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	I491V	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	I517L	-	-	Chlamydia trachomatis	rifampicin	Reslit	Candidate
rpoB RNA polymerase subunit	I517M	-	-	Chlamydia trachomatis	rifampicin	Reslit	Supported
rpoB	I527F	-	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus aureus	rifampicin	Reference Gene CatalogResFinder Database	Confirmed
rpoB RNA polymerase beta-subunit	I527L	-	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus aureus	rifampicin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	I527M	C1583G C1582G A1580G	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus epidermidis, Staphylococcus aureus	rifampicinvancomycinteicoplanin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	I527P	A1580C	-	Staphylococcus aureus	rifampicin	Reslit	Candidate