Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	H445Y	CAT->TAT CAC->TAT GTT->TAT C1333T CTG->TAT C1335T	disrupts an intermolecular hydrogen bond between histidine and rifampicin and introduces an aromatic ring that sterically interferes with rifampicin binding, The rpoB H445Y mutation in Mtb is associated with an increased transcription elongation rate, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis, Mycobacterium smegmatis, Escherichia coli, Mycobacterium bovis	RifampicinCapreomycinCAP