Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB β subunit of RNA polymerase	S530Y	-	-	Listeria monocytogenes	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531A	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	S531C	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531D	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531E	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531F	TCA -> TTC TCA->TTC	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Escherichia coli, Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium gastri, Shigella sonnei	rifampicinrifabutinrifapentine+1 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	S531H	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531K	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531L	TCA->CTA TCG-TTG TCT -> CTT TCA -> TTC AGT->CTT AGC->CTC TCC->CTC	disrupted the intermolecular hydrogen bond between wild-type Ser531 and the RIF molecule, reduces susceptibility, disorders the RIF-binding pocket upon RMP binding and therefore reduces the binding affinity for RMP	Mycobacterium tuberculosis, Mycobacterium simiae, Mycobacterium smegmatis, Rhodococcus equi, Escherichia coli, Mycobacterium avium, Salmonella enterica, Mycobacterium bovis	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	S531P	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate