Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpsJ ribosomal protein S10	V57D	-	30S ribosomal protein S10	Escherichia coli	tetracyclinetigecyclineminocycline	Reference Gene CatalogReslit	Confirmed
rpsJ ribosomal protein S10	V57G	-	causally associated with reduced susceptibility to tetracyclines	Escherichia coli, Treponema porcinum, Treponema spp., Spirochaeta spp.	tetracyclinetigecyclineminocycline	Reslit	Candidate
rpsJ ribosomal protein S10	V57I	G171A G170A	30S ribosomal protein S10	Klebsiella pneumoniae, Escherichia coli, Spirochaeta spp., Acinetobacter baumannii	tigecyclinetetracyclineminocycline	Reference Gene CatalogReslit	Confirmed
rpsJ ribosomal protein S10	V57K	-	causally associated with reduced susceptibility to tetracyclines	Escherichia coli, Spirochaeta spp., Other Treponema	tetracycline	Reslit	Candidate
rpsJ ribosomal protein S10	V57L	G170T G171C G170C	altered ribosome structure near the tigecycline-binding site or interfering with the coordination of Mg 2+ ions, which resulted in reduced tigecycline binding to the 16S rRNA therefore reduced the tigecycline susceptibility, 30S ribosomal protein S10	Neisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Stenotrophomonas maltophilia, Neisseria meningitidis	tetracyclinetigecyclineminocycline	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsJ 30S ribosomal protein S10	V57M	G171A	reduced affinity of 30S ribosome for tetracycline, reduces the affinity between tetracycline and the 30S ribosomal target, Reduced affinity of 30S ribosome for tetracycline, disrupts binding of the antimicrobial to ribosome, 30S ribosomal protein S10	Neisseria gonorrhoeae, Neisseria elongata, Neisseria cinerea, Neisseria subflava, Neisseria canis, N. elongata, Neisseria commensals, Neisseria meningitidis	tetracyclinedoxycyclinemacrolides+1 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpsJ ribosomal protein S10	V57N	-	-	Escherichia coli	tetracyclinetigecyclineminocycline	Reslit	Candidate
rpsJ	V57Q	-	30S ribosomal protein S10	Neisseria gonorrhoeae, Neisseria meningitidis	tetracycline	Reference Gene CatalogResFinder Database	Confirmed
rpsJ ribosomal protein S10	V57R	-	-	Escherichia coli	tetracyclinetigecyclineminocycline	Reslit	Candidate
rpsJ ribosomal S10 protein	Y58D	-	contributes to the resistance to the third-generation tetracycline, 30S ribosomal protein S10	Staphylococcus aureus, Enterococcus faecium, Staphylococcus lugdunensis	tigecyclineeravacyclineomadacycline	Reference Gene CatalogReslit	Confirmed