Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| - | - | Mycobacterium tuberculosis | Para-aminosalicyclic acid | ResFinder Database | Established | ||
| - | - |
Para-aminosalicyclic acid |
ResFinder Database |
| Established |
| 264fs | - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| 39fs | - | - | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| A113G | - | - | Mycobacterium tuberculosis | Trimethoprim | Reslit | Candidate |
| A114V | - | - | - | Para-aminosalicylic acid | Reslit | Candidate |
| A182P | - | The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms. | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| C146R | - | The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms. | Mycobacterium tuberculosis | Para-aminosalicylic acid | Reslit | Candidate |
| C161T | - | single resistance variant | Mycobacterium tuberculosis | Para-aminosalicylic acid | Card Database | Established |
| C161Y | - | - | Mycobacterium tuberculosis | Para-aminosalicyclic acid | ResFinder Database | Established |
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