Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| N60I | - | Target modification, dihydrofolate reductase DfrB | Staphylococcus aureus | trimethoprim | Reference Gene CatalogResFinder Database | Confirmed | |
dfrB dihydrofolate reductase | T96I | - | - | Staphylococcus aureus | trimethoprim sulfamethoxazole | Reslit | Candidate |
dfrB dihydrofolate reductase | V72E | - | - | - | trimethoprim | Reslit | Candidate |
dfrB dihydrofolate reductase | V76A | - | - | Staphylococcus aureus | trimethoprim | Reslit | Candidate |
dfrB dihydrofolate reductase | W38F | - | impedes the formation of functional tetramer, resulting in 10- and 40-fold weaker effective binding to DHF and NADPH, respectively, and a 100-fold reduced catalytic turnover | E. coli | trimethoprim | Reslit | Candidate |
dfrC dihydrofolate reductase | F98Y | - | - | - | trimethoprim | Reslit | Candidate |
dfrC dihydrofolate reductase | H149R | - | - | - | trimethoprim | Reslit | Candidate |
dfrC dihydrofolate reductase | L20I | - | - | - | trimethoprim | Reslit | Candidate |
dgcJ diguanylate cyclase | L152R | - | - | E. coli | kanamycin | Reslit | Candidate |
dgkA diacylglycerol kinase | G106E | - | - | Enterococcus faecium | daptomycin | Reslit | Candidate |
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