Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
ileS isoleucyl-tRNA synthetase | F227L | - | F227L are on the outer surface adjacent to the tRNA molecule about 20 Å from the editing active site | Staphylococcus aureus | mupirocin | Reslit | Candidate |
| F563L | - | isoleucine--tRNA ligase IleS | Staphylococcus aureus | mupirocin | Reference Gene Catalog | Established | |
ileS mupirocin target | G591S | - | - | Staphylococcus aureus | mupirocin | Reslit | Candidate |
ileS mupirocin target | G593A | - | - | Staphylococcus aureus | mupirocin | Reslit | Candidate |
| G593V | - | isoleucine--tRNA ligase IleS | Staphylococcus aureus | mupirocin | Reference Gene Catalog | Established | |
| H67Q | - | isoleucine--tRNA ligase IleS | Staphylococcus aureus | mupirocin | Reference Gene Catalog | Established | |
ileS isoleucyl-tRNA synthetase | I637V | - | - | Staphylococcus aureus | mupirocin | Reslit | Candidate |
ileS isoleucyl-tRNA synthetase | K226T | - | K226T are on the outer surface adjacent to the tRNA molecule about 20 Å from the editing active site | Staphylococcus aureus | mupirocin | Reslit | Candidate |
ileS isoleucyl tRNA synthetase | N213D | - | - | Staphylococcus aureus | mupirocin | Reslit | Candidate |
ileS isoleucyl-tRNA synthetase | P187F | - | mutation of this residue causes steric repulsion to mupirocin | Staphylococcus aureus | mupirocin | Reslit | Candidate |
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