Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ileS isoleucyl-tRNA synthetase	Q612H	-	Q612H has potential to interact with mupirocin. Q612 sits close to the core of IleS Rossman fold motif, where it forms a water-bridged hydrogen bond with the side chain of D635	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS	R816C	-	isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Reference Gene Catalog	Established
ileS isoleucyl-tRNA synthetase	V588F	G1762T	V588 is located in a hydrophobic pocket that interacts directly with the fatty acid side chain of mupirocin, mutation of this residue causes steric repulsion to mupirocin, Target modification, single resistance variant, isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
ileS isoleucyl-tRNA synthetase	V631F	-	Target modification, single resistance variant, isoleucine--tRNA ligase IleS	Staphylococcus aureus	mupirocin	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
ileS isoleucyl-tRNA synthetase	V767D	-	V767D lies in the interior surface of the cylindrical central helical domain of the IleS, distal to the tRNA binding site	Staphylococcus aureus	mupirocin	Reslit	Candidate
ileS isoleucyl-tRNA synthetase (IleRS)	Y723H	-	-	Staphylococcus aureus, Escherichia coli	vancomycin	Reslit	Candidate
inbr	L17Q	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Established
inbr	R9H	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Established
infB translation initiation factor IF-2	-	A184G	-	Helicobacter pylori	clarithromycin	Reslit	Candidate
infB translation initiation factor IF-2	-	A412G	-	Helicobacter pylori	clarithromycin	Reslit	Candidate