Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2 penicillin-binding protein 2	G542S	-	single resistance variant	Neisseria gonorrhoeae	ceftriaxonecefiximebeta lactams	Card DatabaseReslit	Confirmed
pbp2 penicillin-binding protein 2	G545S	-	reduced acylation rates and increased resistance to cephalosporins, lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant	Neisseria gonorrhoeae, Neisseria meningitidis	cefiximeceftriaxoneceftazidime+1 more	Card DatabaseReslit	Confirmed
pbp2 penicillin-binding protein 2	G581D	-	-	Staphylococcus aureus	ceftaroline	Reslit	Candidate
pbp2 beta-lactam target	G593A	-	-	-	beta lactams	Reslit	Candidate
pbp2 penicillin-binding protein	G608D	-	-	Burkholderia pseudomallei	beta lactams	Reslit	Candidate
pbp2 penicillin-binding protein 2	G631S	-	-	Staphylococcus aureus	ceftaroline	Reslit	Candidate
pbp2 penicillin-binding protein 2	H121R	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
pbp2 penicillin-binding protein 2	H371A	-	-	Acinetobacter baumannii	carbapenemscephalosporins	Reslit	Candidate
pbp2 penicillin-binding protein 2	H541N	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
pbp2	I259T	-	single resistance variant	Helicobacter pylori	amoxicillin	Card Database	Established